Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics

doi:10.1039/c8cs00081f

	Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics
	Pan, Limin; Liu, Jianan; Shi, Jianlin
刊名	CHEMICAL SOCIETY REVIEWS
	2018
卷号	47 期号:18 页码:6930
ISSN号	0306-0012
DOI	10.1039/c8cs00081f
英文摘要	Tumor therapeutic efficacy is determined, to a great extent, by the delivery efficiency of therapeutic drugs to their final targets. The cell nucleus has been proven to be the main interaction site for most therapeutic agents such as anticancer drugs, genes, free radicals, and heat. Therefore, it is highly expected that cell nucleus-targeting or nuclear membrane-penetrating nanotherapeutics would provide a more effective strategy than ordinary cell membrane-targeting ones for benefiting precise nanomedicine in humans' battles against cancer. This tutorial review presents a summary of the most recent progress achieved in the design, synthesis, and application of cell nucleus-targeting nanotherapeutics. We first discuss a number of design principles involved in cell nucleus-targeting nanotherapeutics, including size control, shape regulation, and surface modification. Next, we demonstrate the diverse applications of cell nucleus-targeting nanotherapeutics ranging from chemotherapy, gene therapy, photodynamic therapy, photothermal therapy to synergistic therapy. Moreover, a number of typical nanotherapeutics designed for enhanced therapeutic efficacy by targeting other subcellular organelles (such as mitochondria, lysosomes, and endoplasmic reticulum) are also briefly discussed. Finally, perspectives and challenges in this research field are proposed, in the hope of accelerating their translation into the clinic.
学科主题	Chemistry, Multidisciplinary
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000444811300003
资助机构	This work was financially supported by the National Natural Science Foundation of China (Grant No. 51502326), the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (YESS20160052), and the Youth Innovation Promotion Association of Chinese Academy of Sciences. ; This work was financially supported by the National Natural Science Foundation of China (Grant No. 51502326), the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (YESS20160052), and the Youth Innovation Promotion Association of Chinese Academy of Sciences.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24670]
专题	中国科学院上海硅酸盐研究所
作者单位	Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Pan, Limin,Liu, Jianan,Shi, Jianlin. Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics[J]. CHEMICAL SOCIETY REVIEWS,2018,47(18):6930, 6946.
APA	Pan, Limin,Liu, Jianan,&Shi, Jianlin.(2018).Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics.CHEMICAL SOCIETY REVIEWS,47(18),6930.
MLA	Pan, Limin,et al."Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics".CHEMICAL SOCIETY REVIEWS 47.18(2018):6930.