Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation

doi:10.1016/j.biomaterials.2017.11.015

	Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation
	Liu, Zhuang 1; Zhang, Shengjian 1; Lin, Han 2,3; Zhao, Menglong 4,5; Yao, Heliang 2; Zhang, Linlin 2; Peng, Weijun 1; Chen, Yu 2
刊名	BIOMATERIALS
	2018
卷号	155 页码:54
关键词	MnO2 nanosheets Stimuli-responsive Degradable Magnetic resonance imaging Photothermal therapy
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2017.11.015
英文摘要	The fabrication of functional nanoparticles with unique ultra-sensitivity to endogenous tumor micro environment (TME) is of great significance for their improved theranostic performance and easy excretion out of the body, which has not been realized among diverse nano-sized photothermal agents for photothermal therapy (PTT) of tumor. In this work, we report on the synthesis of 2D ultrathin MnO2 nanosheets for highly efficient PTT against tumor with ultra-sensitivity to endogenous TME. These ultrathin 2D MnO2 nanosheets show the intriguing characteristic of disintegration and releasing of Mn2+ in response to the mild acidic condition and elevated reducing microenvironment of TME, which has successfully realized the pH- and reducing-responsive T-1-weighted magnetic resonance imaging of tumor. Importantly, the high PTT efficiency of 2D MnO2 nanosheets responsive to exogenous NIR irradiation has been systematically demonstrated both in vitro and in vivo for suppressing the tumor growth. This first report on the exploring of TME-sensitive photothermal agents with concurrent diagnostic and therapeutic (theranostic) functions significantly broadens the biomedical application of 2D functional biomaterials, which also promotes the further potential clinical translations of nano-sized photothermal agents. (C) 2017 Elsevier Ltd. All rights reserved.
学科主题	Engineering, Biomedical ; Materials Science, bioMaterials
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000419539000005
资助机构	We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), Natural Science Foundation of Shanghai (15ZR1407700), National Natural Science Foundation of China (5130 51722211 and 51672303), Young Elite Scientist Sponsorship Program by CAST (2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169) and Development Fund for Shanghai Talents (2015). We also acknowledge Prof. Lianzhou Wang and Dr. Delai Ye from the University of Queensland for their helpful guidance of the preparation of 2D MnO2 nanosheets. ; We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), Natural Science Foundation of Shanghai (15ZR1407700), National Natural Science Foundation of China (5130 51722211 and 51672303), Young Elite Scientist Sponsorship Program by CAST (2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169) and Development Fund for Shanghai Talents (2015). We also acknowledge Prof. Lianzhou Wang and Dr. Delai Ye from the University of Queensland for their helpful guidance of the preparation of 2D MnO2 nanosheets.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24521]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Fudan Univ, Dept Radiol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China 2.Fudan Univ, Dept Oncol, Shanghai Med Coll, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Fudan Univ, Dept Radiol, Zhongshan Hosp, Shanghai Med Coll, Shanghai 200032, Peoples R China 6.Shanghai Inst Med Imaging, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhuang,Zhang, Shengjian,Lin, Han,et al. Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation[J]. BIOMATERIALS,2018,155:54, 63.
APA	Liu, Zhuang.,Zhang, Shengjian.,Lin, Han.,Zhao, Menglong.,Yao, Heliang.,...&Chen, Yu.(2018).Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation.BIOMATERIALS,155,54.
MLA	Liu, Zhuang,et al."Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation".BIOMATERIALS 155(2018):54.