Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway

doi:10.1039/c7bm01044c

	Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway
	Zhang, Xinran ; Li, Haotian 1; Lin, Chucheng 2; Ning, Congqin 2; Lin, Kaili 3
刊名	BIOMATERIALS SCIENCE
	2018
卷号	6 期号:2 页码:418
ISSN号	2047-4830
DOI	10.1039/c7bm01044c
英文摘要	Both the topographic surface and chemical composition modification can enhance rapid osteogenic differentiation and bone formation. Till now, the synergetic effects of topography and chemistry cues guiding biological responses have been rarely reported. Herein, the ordered micro-patterned topography and classically essential trace element of strontium (Sr) ion doping were selected to imitate topography and chemistry cues, respectively. The ordered micro-patterned topography on Sr ion-doped bioceramics was successfully duplicated using the nylon sieve as the template. Biological response results revealed that the micro-patterned topography design or Sr doping could promote cell attachment, ALP activity, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Most importantly, the samples both with micro-patterned topography and Sr doping showed the highest promotion effects, and could synergistically activate the ERK1/2 and p38 MAPK signaling pathways. The results suggested that the grafts with both specific topography and chemistry cues have synergetic effects on osteogenic activity of BMSCs and provide an effective approach to design functional bone grafts and cell culture substrates.
学科主题	Materials Science, bioMaterials
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000423742400018
资助机构	The authors gratefully acknowledge the support of the Natural Science Foundation of China (No. 81672134) and Science and Technology Commission of Shanghai Municipality (No. 15441905300), the Fund of Shanghai Municipal Commission of Health and Family Planning (No. 201540369), and the Fund Supported by the Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure (No. SKL201610SIC). ; The authors gratefully acknowledge the support of the Natural Science Foundation of China (No. 81672134) and Science and Technology Commission of Shanghai Municipality (No. 15441905300), the Fund of Shanghai Municipal Commission of Health and Family Planning (No. 201540369), and the Fund Supported by the Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure (No. SKL201610SIC).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24518]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Tongji Univ, Sch & Hosp Stomatol, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Shanghai 200072, Peoples R China 2.Tongji Univ, Tongji Hosp, Sch Med, Dept Spine Surg, Shanghai 200065, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 4.State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xinran,Li, Haotian,Lin, Chucheng,et al. Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway[J]. BIOMATERIALS SCIENCE,2018,6(2):418, 430.
APA	Zhang, Xinran,Li, Haotian,Lin, Chucheng,Ning, Congqin,&Lin, Kaili.(2018).Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway.BIOMATERIALS SCIENCE,6(2),418.
MLA	Zhang, Xinran,et al."Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway".BIOMATERIALS SCIENCE 6.2(2018):418.