Smart release of doxorubicin loaded on polyetheretherketone (PEEK) surface with 3D porous structure

doi:10.1016/j.colsurfb.2017.12.045

	Smart release of doxorubicin loaded on polyetheretherketone (PEEK) surface with 3D porous structure
	Ouyang, Liping 1; Sun, Zhenjie 2; Wang, Donghui 1; Qiao, Yuqin ; Zhu, Hongqin ; Ma, Xiaohan ; Liu, Xuanyong
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2018
卷号	163 页码:175
关键词	Polyetheretherketone Chitosan Doxorubicin Controlled release
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2017.12.045
英文摘要	It is important to fabricate an implant possessing environment sensitive drug delivery. In this work, the construction of 3D porous structure on polyetheretherketone (PEEK) surface and pH sensitive polymer, chitosan, was introduced. The smart release of doxorubicin can be realized on the 3D porous surface of PEEK loading chitosan. We give a feasible explanation for the effect of chitosan on smart drug release according to Henderson-Hasselbalch equation. Furthermore, the intracellular drug content of the cell cultured on the samples with highest chitosan is significantly higher at pH 4.0, whereas lower at pH 7.4 than other samples. The smart release of doxorubicin via modification with chitosan onto 3D porous PEEK surface paves the way for the application of PEEK in drug loading platform for recovering bone defect caused by malignant bone tumor. (C) 2017 Elsevier B.V. All rights reserved.
学科主题	Biophysics ; Chemistry, Physical ; Materials Science, bioMaterials
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000427217300021
资助机构	This work was supported by the National Science Foundation for Distinguished Young Scholars of China (51525207) ; National Natural Science Foundation of China (31570973) ; and Shanghai Committee of Science and Technology, China (16441904600). ; This work was supported by the National Science Foundation for Distinguished Young Scholars of China (51525207) ; National Natural Science Foundation of China (31570973) ; and Shanghai Committee of Science and Technology, China (16441904600).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24436]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Normal Univ, Dept Chem, Shanghai 200234, Peoples R China
推荐引用方式 GB/T 7714	Ouyang, Liping,Sun, Zhenjie,Wang, Donghui,et al. Smart release of doxorubicin loaded on polyetheretherketone (PEEK) surface with 3D porous structure[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,163:175, 183.
APA	Ouyang, Liping.,Sun, Zhenjie.,Wang, Donghui.,Qiao, Yuqin.,Zhu, Hongqin.,...&Liu, Xuanyong.(2018).Smart release of doxorubicin loaded on polyetheretherketone (PEEK) surface with 3D porous structure.COLLOIDS AND SURFACES B-BIOINTERFACES,163,175.
MLA	Ouyang, Liping,et al."Smart release of doxorubicin loaded on polyetheretherketone (PEEK) surface with 3D porous structure".COLLOIDS AND SURFACES B-BIOINTERFACES 163(2018):175.