Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study | |
Luo, Xiaoyu1,2; Qi, Yu1; Wang, Hesheng1; Wang, Yijun1; He, Tingyu1; Rong, Bei1; Liu, Zhongchun1; Zhou, Yuan6,7; Wang, Gaohua1,4,5; Wang, Huiling1,3 | |
刊名 | NEUROSCIENCE LETTERS |
2018-11-01 | |
卷号 | 686页码:101-105 |
关键词 | Schizophrenia Prefrontal Cortex (Pfc) Atypical Antipsychotics Verbal Fluency Task (Vft) Near-infrared Spectroscopy (Nirs) |
ISSN号 | 0304-3940 |
DOI | 10.1016/j.neulet.2018.09.001 |
产权排序 | 6 |
文献子类 | Article |
英文摘要 | A number of near-infrared spectroscopy (NIRS) studies in schizophrenia have shown that there is a significant dysfunction of the prefrontal cortex (PFC) in patients with schizophrenia, but it remains unclear how atypical antipsychotics affect the function of the PFC. To investigate the changes in brain activation patterns in schizophrenia who accepted antipsychotic treatment, we used NIRS to measure the hemodynamic changes of the PFC in patients with schizophrenia at the time of enrollment and after 4 weeks of treatment during a verbal fluency task (VFT). We included 16 schizophrenia and 17 sex- and age- matched healthy controls. Compared with the healthy controls, the VFT performance was significantly worse in patients with schizophrenia, as was the activation of the PFC. Furthermore, after 4 weeks of treatment, there was no significant improvement in VFT performance and the activation of the PFC in schizophrenia. Our results suggest that the function of the PFC and cognitive skills in schizophrenia were significantly impaired and do not improve from a short-term treatment of atypical antipsychotics. |
资助项目 | National Science and Technologic Program of China[2015BAI13B02] ; National Natural Science Foundation of China[91132301] ; Natural Science Foundation of Hubei Province[014CFB732] |
WOS关键词 | Major Depressive Disorder ; 1st-episode Schizophrenia ; Drug-naive ; Association ; Activation ; Improvement ; Impairment ; Symptoms |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER IRELAND LTD |
WOS记录号 | WOS:000449897900016 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/27553] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Wang, Huiling |
作者单位 | 1.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Hubei, Peoples R China 2.Wuhan Wuchang Hosp, Dept Psychiat, Wuhan 430000, Hubei, Peoples R China 3.Hubei Prov Key Lab Developmentally Originated Dis, Wuhan 430071, Hubei, Peoples R China 4.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Hubei, Peoples R China 5.Hubei Univ Sci & Technol, Xianning 437100, Peoples R China 6.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Luo, Xiaoyu,Qi, Yu,Wang, Hesheng,et al. Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study[J]. NEUROSCIENCE LETTERS,2018,686:101-105. |
APA | Luo, Xiaoyu.,Qi, Yu.,Wang, Hesheng.,Wang, Yijun.,He, Tingyu.,...&Wang, Huiling.(2018).Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study.NEUROSCIENCE LETTERS,686,101-105. |
MLA | Luo, Xiaoyu,et al."Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study".NEUROSCIENCE LETTERS 686(2018):101-105. |
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