Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2018专题

	Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform
	Sun, Peng; Li, Zhen; Wang, Jingyun; Gao, Hui; Yang, Xi; Wu, Sudong; Liu, Deqiang; Chen, Qixian
刊名	CHEMICAL COMMUNICATIONS
	2018
卷号	54 期号:80 页码:11304-11307
关键词	Gene Delivery Transfection Polyplexes Polymers Therapy Systems Safe
英文摘要	A supramolecular catiomer with a metal-organic framework (MOF) motif was developed to manufacture messenger RNA (mRNA) assemblies. In contrast to the linear catiomer, the dendritic MOF catiomer appeared to markedly improve the colloidal stability of the mRNA assemblies, particularly affording substantial protection to the mRNA payloads from enzymatic degradation, eventually conducing to appreciable mRNA transfection activities at the targeted cells.
学科主题	Chemistry ; Materials Science
语种	英语
公开日期	2018-12-04
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/17126]
专题	2018专题
推荐引用方式 GB/T 7714	Sun, Peng,Li, Zhen,Wang, Jingyun,et al. Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform[J]. CHEMICAL COMMUNICATIONS,2018,54(80):11304-11307.
APA	Sun, Peng.,Li, Zhen.,Wang, Jingyun.,Gao, Hui.,Yang, Xi.,...&Chen, Qixian.(2018).Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform.CHEMICAL COMMUNICATIONS,54(80),11304-11307.
MLA	Sun, Peng,et al."Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform".CHEMICAL COMMUNICATIONS 54.80(2018):11304-11307.