Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment | |
Lu, Zhiguo1,2; Li, Yan1; Shi, Yuanjie1; Li, Yanhui1; Xiao, Zuobing3,4; Zhang, Xin1 | |
刊名 | ADVANCED FUNCTIONAL MATERIALS |
2017-12-08 | |
卷号 | 27期号:46页码:1 |
关键词 | Card-b6 Doxorubicin Glioblastoma Multiforme Spatiotemporally Controlled Release Synergistic Treatment |
ISSN号 | 1616-301X |
DOI | 10.1002/adfm.201703967 |
文献子类 | Article |
英文摘要 | Doxorubicin (DOX), one of the most widely used clinical antineoplastics, has ineffective therapeutic efficacy on glioblastoma multiforme (GBM) with extremely short survival time due to many obstacles such as blood-brain barrier (BBB), tumor angiogenesis, and glioblastoma stem cells (GSCs). To overcome, biocompatible nanoparticles named CARD-B6 loading three clinical drugs are developed. Unlike other nanomedicines, CARD-B6, with the ability of spatiotemporally controlled release, maximize the effectiveness of DOX. (1) After CARD-B6 cross the BBB via B6, combretastatin A4 that is first released via protonation of poly (-amino ester) specifically destroys angiogenesis to facilitate the interaction between GBM and CARD-B6. (2) Internalized into glioblastoma cells later, DOX is released via the breakage of amido bond to induce apoptosis, which is facilitated by the simultaneously released all-trans retinoic acid (ATRA). (3) After endocytosis into GSCs, the rapidly released ATRA induces the GSCs differentiation and downregulates the survival pathways, which enhances the sensitivity of GSCs to the subsequently released DOX. This synergistic antitumor effect significantly extends survival time of GBM mouse model. CARD-B6 are traced by superparamagnetic iron oxide nanocubes with high r(2) relaxivity for magnetic resonance imaging. Therefore, the traceable CARD-B6 with spatiotemporally controlled release ability are emerging as a powerful platform for GBM treatment. |
WOS关键词 | Blood-brain-barrier ; Trans-retinoic Acid ; Cancer Stem-cells ; In-vivo ; U87mg Cells ; Therapy ; Glioma ; Tumors ; Delivery ; Differentiation |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
WOS记录号 | WOS:000417187200017 |
资助机构 | National High Technology Research and Development Program(2016YFA0200303) ; Beijing Natural Science Foundation(2164071) ; National Natural Science Foundation of China(31522023 ; Beijing Municipal Science & Technology Commission(Z161100002616015) ; Chinese Academy of Sciences(XDA09030301-3) ; 51373177 ; 51573188) |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/23485] |
专题 | 过程工程研究所_研究所(批量导入) |
通讯作者 | Zhang, Xin |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China 3.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China 4.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China |
推荐引用方式 GB/T 7714 | Lu, Zhiguo,Li, Yan,Shi, Yuanjie,et al. Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(46):1. |
APA | Lu, Zhiguo,Li, Yan,Shi, Yuanjie,Li, Yanhui,Xiao, Zuobing,&Zhang, Xin.(2017).Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment.ADVANCED FUNCTIONAL MATERIALS,27(46),1. |
MLA | Lu, Zhiguo,et al."Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment".ADVANCED FUNCTIONAL MATERIALS 27.46(2017):1. |
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