RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review | |
Qiao, Chenmeng1,2,3; Yang, Jun1; Shen, Qi1,4; Shen, Yan-Qin3; Weng, Jie2; Zhang, Xin1 | |
刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY |
2017-08-01 | |
卷号 | 13期号:8页码:891-910 |
关键词 | Rnai-based Immune Modulation The Immunosuppressive Tumor Microenvironment Glioblastoma Immunity Responses Rna Therapeutics |
ISSN号 | 1550-7033 |
DOI | 10.1166/jbn.2017.2388 |
文献子类 | Review |
英文摘要 | Glioblastoma is the most common and devastating primary brain tumor in adults. The clinical treatments of glioblastoma are generally focus on surgical excision, chemotherapy and radiotherapy, while the prognosis remains grim. With the adequate understanding of the unique immunological microenvironment in the central nervous system (CNS) and CNS tumors, immune microenvironment modulation becomes a promising treatment modality in glioma. Studies using RNA interference (RNAi) technology to modulate the immune microenvironment are under an active investigation. Using those therapeutic strategies directly or indirectly react with tumor cells, antigen processing cells (APCs, including microglia and dendritic cells (DCs)) and immune cells (such as T cells and natural killer cells (NK cells)) has been extensively studied. Here, we review the current advances in immune microenvironment modulation for glioblastoma with RNAi approach. We also investigate how the factors, associated with immunosuppression, to combat with glioblastoma, and discuss the deficiency for this anti-glioblastoma strategy. From these, we expect to provide a guidance for the future development of RNAi-based immunomodulation strategy for glioblastoma and establish optimized antitumor therapy for clinical treatments. |
WOS关键词 | Central-nervous-system ; Blood-brain-barrier ; Regulatory T-cells ; Glioma-infiltrating Microglia/macrophages ; Junction Protein Connexin43 ; Antigen Cross-presentation ; Temozolomide Co-delivery ; Growth-factor-receptor ; Dendritic Cells ; Tumor Microenvironment |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
WOS记录号 | WOS:000414565900003 |
资助机构 | National High Technology Research and Development Program(2016YFA0200303) ; National Natural Science Foundation of China(51373177 ; Beijing Municipal Science and Technology Commission(Z161100002616015) ; Beijing Natural Science Foundation(2164071) ; Chinese Academy of Sciences(XDA09030301-3) ; 51573188 ; 31522023) |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/23403] |
专题 | 过程工程研究所_生化工程国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China 3.Jiangnan Univ, Wuxi Med Coll, Wuxi 214122, Peoples R China 4.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China |
推荐引用方式 GB/T 7714 | Qiao, Chenmeng,Yang, Jun,Shen, Qi,et al. RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(8):891-910. |
APA | Qiao, Chenmeng,Yang, Jun,Shen, Qi,Shen, Yan-Qin,Weng, Jie,&Zhang, Xin.(2017).RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(8),891-910. |
MLA | Qiao, Chenmeng,et al."RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13.8(2017):891-910. |
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