Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice

doi:10.1007/s12576-017-0561-9

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	Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice
	Zhu, Lin 1; Chi, Tianyan 1; Zhao, Xuemei 1; Yang, Lei 1; Song, Shijie 1; Lu, Qiaohui 1; Ji, Xuefei 1; Liu, Peng 1; Wang, Lihua 2; Zou, Libo 1
刊名	JOURNAL OF PHYSIOLOGICAL SCIENCES
	2018-09-01
卷号	68 期号:5 页码:555-565
关键词	Alzheimer's Disease Xanthoceraside Neurogenesis Learning And Memory Wnt/beta-catenin Pathway
ISSN号	1880-6546
DOI	10.1007/s12576-017-0561-9
英文摘要	Neuronal loss is reported to be an important pathological process in Alzheimer's disease (AD). Neurogenesis is a process of generation of new neurons to fill the neuronal loss. Xanthoceraside has been shown to attenuate the cognitive deficits in several AD animal models. However, little is known about the effect of xanthoceraside on neurogenesis in APP/PS1 transgenic mice. Thus, in this study, we investigated whether xanthoceraside can ameliorate learning and memory impairment by promoting NSCs proliferation and neuronal differentiation. The results suggested that xanthoceraside significantly ameliorated the cognitive impairment and induced NSCs proliferation and neuronal differentiation in APP/PS1 transgenic mice. Meanwhile, in vitro study revealed that xanthoceraside increased the size of NSCs and induced NSCs differentiation into neurons compared with amyloid beta-peptide (25-35) (A beta(25-35)) treatment. Furthermore, we found that xanthoceraside significantly increased the expression of Wnt3a and p-GSK3 beta, decreased the expression of p-beta-catenin, and induced nuclear translocation of beta-catenin in APP/PS1 transgenic mice. Furthermore, in vitro study found that the effect of xanthoceraside on inducing NSCs proliferation and neuronal differentiation were inhibited by Wnt pathway inhibitor Dickkopf-1 (Dkk-1). Our data demonstrated that xanthoceraside may promote the proliferation and differentiation of NSCs into neurons by up-regulating the Wnt/beta-catenin pathway to fill the neuronal loss, thereby improving learning and memory impairment in APP/PS1 transgenic mice.
WOS研究方向	Physiology
语种	英语
出版者	SPRINGER JAPAN KK
WOS记录号	WOS:000440613200003
内容类型	期刊论文
源URL	[http://210.72.129.5/handle/321005/106437]
专题	沈阳应用生态研究所_沈阳应用生态研究所_期刊论文
通讯作者	Zou, Libo
作者单位	1.Shenyang Pharmaceut Univ, Dept Pharmacol, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 2.Chinese Acad Sci, Shenyang Inst Appl Ecol, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Lin,Chi, Tianyan,Zhao, Xuemei,et al. Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice[J]. JOURNAL OF PHYSIOLOGICAL SCIENCES,2018,68(5):555-565.
APA	Zhu, Lin.,Chi, Tianyan.,Zhao, Xuemei.,Yang, Lei.,Song, Shijie.,...&Zou, Libo.(2018).Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice.JOURNAL OF PHYSIOLOGICAL SCIENCES,68(5),555-565.
MLA	Zhu, Lin,et al."Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice".JOURNAL OF PHYSIOLOGICAL SCIENCES 68.5(2018):555-565.