Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers

doi:10.1039/c4lc01216j

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	Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers
	Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.; Liu C(刘超); Hu GQ(胡国庆); Jiang XY; Sun JS
刊名	Lab on A Chip
	2015
卷号	15 期号:4 页码:1168-1177
ISSN号	1473-0197
DOI	10.1039/c4lc01216j
产权排序	[Liu, Chao; Hu, Guoqing] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; [Jiang, Xingyu; Sun, Jiashu] Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China; [Jiang, Xingyu; Sun, Jiashu] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat Nanosafety, Beijing 100190, Peoples R China
文献子类	Article
英文摘要	Inertial microfluidics has emerged as an important tool for manipulating particles and cells. For a better design of inertial microfluidic devices, we conduct 3D direct numerical simulations (DNS) and experiments to determine the complicated dependence of focusing behaviour on the particle size, channel aspect ratio, and channel Reynolds number. We find that the well-known focusing of the particles at the two centers of the long channel walls occurs at a relatively low Reynolds number, whereas additional stable equilibrium positions emerge close to the short walls with increasing Reynolds number. Based on the numerically calculated trajectories of particles, we propose a two-stage particle migration which is consistent with experimental observations. We further present a general criterion to secure good focusing of particles for high flow rates. This work thus provides physical insight into the multiplex focusing of particles in rectangular microchannels with different geometries and Reynolds numbers, and paves the way for efficiently designing inertial microfluidic devices.
学科主题	Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
分类号	一类
URL标识	查看原文
语种	英语
WOS记录号	WOS:000349404200028
资助机构	We thank the Ministry of Science and Technology (2011CB707604 and 2013AA032204) and the National Science Foundation of China (11272321, 21475028, and 51105086) for financial support. We sincerely thank Dr. William D. Henshaw for making the finite-difference code - overture available to us. The numerical simulations were performed on TianHe-1(A) at the National Supercomputing Center in Tianjin.
公开日期	2015-03-17
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/49628]
专题	力学研究所_非线性力学国家重点实验室
通讯作者	Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Hu, GQ ,Liu C,Hu GQ,et al. Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers[J]. Lab on A Chip,2015,15(4):1168-1177.
APA	Hu, GQ ,Liu C,Hu GQ,Jiang XY,&Sun JS.(2015).Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers.Lab on A Chip,15(4),1168-1177.
MLA	Hu, GQ ,et al."Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers".Lab on A Chip 15.4(2015):1168-1177.