Efficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum

doi:10.1186/s13068-017-0796-y

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	Efficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum
	Zhang, Jie 1,2,3,4; Liu, Shiyue 1,2,3,4; Li, Renmin 1,2,3,4; Hong, Wei 5; Xiao, Yan 1,2,3; Feng, Yingang 1,2,3; Cui, Qiu 1,2,3; Liu, Ya-Jun 1,2,3
刊名	BIOTECHNOLOGY FOR BIOFUELS
	2017-05-12
卷号	10
关键词	Beta-glucosidase Cellulosome Cels Fermentable Sugar Genome Editing Lignocellulose
DOI	10.1186/s13068-017-0796-y
文献子类	Article
英文摘要	Background: Cost-efficient saccharification is one of the main bottlenecks for industrial lignocellulose conversion. Clostridium thermocellum naturally degrades lignocellulose efficiently using the cellulosome, a multiprotein supermolecular complex, and thus can be potentially used as a low-cost catalyst for lignocellulose saccharification. The industrial use of C. thermocellum is restrained due largely to the inhibition of the hydrolysate cellobiose to its cellulosome. Although the supplementation of beta-glucosidase may solve the problem, the production of the enzymes greatly complicates the process and may also increase the cost of saccharification.
WOS关键词	TARGETED GENE DELETION ; BETA-GLUCOSIDASE ; THERMOANAEROBACTER-BROCKII ; DEGRADATION ; PROTEIN ; MICROBES ; ENZYME ; POLYSACCHARIDES ; SOLUBILIZATION ; INTEGRATION
WOS研究方向	Biotechnology & Applied Microbiology ; Energy & Fuels
语种	英语
WOS记录号	WOS:000401620700001
资助机构	National Natural Science Foundation of China(31300035 ; National Key Technology Research and Development Program of China(2015BAD15B05) ; Shandong Province Key Laboratory Union of Carbohydrate Industry Science and Technology ; 31470210 ; 31560318 ; 31570029 ; 31570787)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/9705]
专题	青岛生物能源与过程研究所_代谢物组学团队
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Energy Genet, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, Qingdao 266101, Peoples R China 3.Chinese Acad Sci, Qingdao Engn Lab Single Cell Oil, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China 5.Guizhou Med Univ, Minist Educ, Key Lab Endem & Ethn Dis, Guiyang 550000, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jie,Liu, Shiyue,Li, Renmin,et al. Efficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum[J]. BIOTECHNOLOGY FOR BIOFUELS,2017,10.
APA	Zhang, Jie.,Liu, Shiyue.,Li, Renmin.,Hong, Wei.,Xiao, Yan.,...&Liu, Ya-Jun.(2017).Efficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum.BIOTECHNOLOGY FOR BIOFUELS,10.
MLA	Zhang, Jie,et al."Efficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum".BIOTECHNOLOGY FOR BIOFUELS 10(2017).