Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis

doi:10.3389/fphar.2018.00057

	Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis
	Zhang, Weidong 1; Zhao, Yong 1,2; Li, Fuli 3; Li, Lan 1; Feng, Yanni 1; Min, Lingjiang 1; Ma, Dongxue 1; Yu, Shuai 1; Liu, Jing 4; Zhang, Hongfu 2
刊名	FRONTIERS IN PHARMACOLOGY
	2018-01-30
卷号	9
关键词	Zinc Oxide Nanoparticles Plasma Metabolomics Perturbation Hepatic Steatosis
ISSN号	1663-9812
DOI	10.3389/fphar.2018.00057
文献子类	Article
英文摘要	Zinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption, are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs. However, they have also been found to adversely affect organisms; previously we found that ZnO NPs disrupt pubertal ovarian development, inhibit embryonic development by upsetting gamma-H2AX and NF-kappa B pathways, and even disturb skin stem cells. Non-targeted metabolomic analysis of biological organisms has been suggested as an unbiased tool for the investigation of perturbations in response to NPs and their underlying mechanisms. Although metabolomics has been used in nanotoxicological studies, very few reports have used it to investigate the effects of ZnO NPs exposure. In the current investigation, through a metabolomics-based approach, we discovered that ZnO NPs caused changes in plasma metabolites involved in anti-oxidative mechanisms, energy metabolism, and lipid metabolism in hen livers. These results are in line with earlier findings that ZnO NPs perturb the tricarboxylic acid cycle and in turn result in the use of alternative energy sources. We also found that ZnO NPs disturbed lipid metabolism in the liver and consequently impacted blood lipid balance. Changes in plasma metabolomes were correlated with hepatic steatosis.
WOS关键词	OXIDATIVE STRESS ; INDUCED HEPATOTOXICITY ; TOXICITY ; RATS ; TAURINE ; CELLS ; EXPOSURE ; LUNG ; NEPHROTOXICITY ; CYTOTOXICITY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000423546900001
资助机构	Agricultural Innovative Project of Shandong Academy of Agricultural Sciences(CXGC2017B02) ; Program for Natural Science Foundation of Shandong Province in China(ZR2015CL045) ; National Natural Science Foundation of China(31302166) ; Qingdao Agricultural University Outstanding Research Foundation
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/10585]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Zhao, Yong; Shen, Wei
作者单位	1.Qingdao Agr Univ, Coll Life Sci, Qingdao, Peoples R China 2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China 4.Qingdao Agr Univ, Core Labs, Qingdao, Peoples R China 5.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Weidong,Zhao, Yong,Li, Fuli,et al. Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis[J]. FRONTIERS IN PHARMACOLOGY,2018,9.
APA	Zhang, Weidong.,Zhao, Yong.,Li, Fuli.,Li, Lan.,Feng, Yanni.,...&Shen, Wei.(2018).Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis.FRONTIERS IN PHARMACOLOGY,9.
MLA	Zhang, Weidong,et al."Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis".FRONTIERS IN PHARMACOLOGY 9(2018).