Biosynthesis and production of sabinene: current state and perspectives

doi:10.1007/s00253-017-8695-5

CORC > 青岛生物能源与过程研究所 > 中国科学院青岛生物能源与过程研究所 > 材料生物技术研究中心

	Biosynthesis and production of sabinene: current state and perspectives
	Cao, Yujin; Zhang, Haibo; Liu, Hui; Liu, Wei; Zhang, Rubing; Xian, Mo; Liu, Huizhou
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2018-02-01
卷号	102 期号:4 页码:1535-1544
关键词	Sabinene Terpene Biosynthetic Pathway Sabinene Synthase Microbial Production
ISSN号	0175-7598
DOI	10.1007/s00253-017-8695-5
文献子类	Review
英文摘要	Sabinene is an important naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Up to now, this valuable terpene is commercially unavailable since there is no applicable manufacturing process. Microbial synthesis can be a promising route for sabinene production. In this review, we summarize knowledge about the metabolic pathway and key enzymes for sabinene biosynthesis. Recent advances that have been made in production of sabinene by microbial fermentation are highlighted. In these studies, researchers have identified the general synthetic pathway of sabinene from simple intermediate metabolites. Sabinene synthases of different origins were also cloned and characterized. Additionally, heterologous systems of the model microbes Escherichia coli and Saccharomyces cerevisiae were constructed to produce sabinene. This review also suggests new directions and attempts to gain some insights for achieving an industrial level production of sabinene. The combination of traditional molecular biology with new genome and proteome analysis tools will provide a better view of sabinene biosynthesis and a greater potential of microbial production.
WOS关键词	CELL-FREE SYSTEMS ; ISOPENTENYL DIPHOSPHATE ; ISOPRENOID BIOSYNTHESIS ; ESCHERICHIA-COLI ; BIOTECHNOLOGICAL PRODUCTION ; SACCHAROMYCES-CEREVISIAE ; MONOTERPENE SYNTHASES ; BORNYL DIPHOSPHATE ; ESSENTIAL OILS ; PATHWAY
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000424053700001
资助机构	National Natural Science Foundation of China(31200030) ; Taishan Scholars Climbing Program of Shandong(tspd20150210)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/10581]
专题	青岛生物能源与过程研究所_材料生物技术研究中心
通讯作者	Xian, Mo; Liu, Huizhou
作者单位	Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Cao, Yujin,Zhang, Haibo,Liu, Hui,et al. Biosynthesis and production of sabinene: current state and perspectives[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018,102(4):1535-1544.
APA	Cao, Yujin.,Zhang, Haibo.,Liu, Hui.,Liu, Wei.,Zhang, Rubing.,...&Liu, Huizhou.(2018).Biosynthesis and production of sabinene: current state and perspectives.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,102(4),1535-1544.
MLA	Cao, Yujin,et al."Biosynthesis and production of sabinene: current state and perspectives".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 102.4(2018):1535-1544.