Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis

doi:10.1016/j.jnutbio.2017.10.011

	Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis
	Tian, Yuan 1,2,3; Nichols, Robert G.3; Cai, Jingwei 3; Patterson, Andrew D.1,3; Cantorna, Margherita T.1
刊名	JOURNAL OF NUTRITIONAL BIOCHEMISTRY
	2018-04-01
卷号	54 页码:28-34
关键词	Vitamin a Microbiota Short-chain Fatty Acids Diabetes Metabolomics
ISSN号	0955-2863
DOI	10.1016/j.jnutbio.2017.10.011
文献子类	Article
英文摘要	Vitamin A deficiency (A) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A) mice using H-1 NMR-based metabolomics, quantitative (q)PCR and 16S rRNA gene sequencing coupled with multivariate data analysis. The microbiota in the cecum of A mice showed compositional as well as functional shifts compared to the microbiota from A+ mice. Targeted 1H NMR analyses revealed significant changes in microbial metabolite concentrations including higher butyrate and hippurate and decreased acetate and 4-hydroxyphenylacetate in A+ relative to A mice. Bacterial butyrate producing genes including butyryl-CoA:acetate CoA-transferase and butyrate kinase were significantly higher in bacteria from A+ versus bacteria from A mice. A mice had disturbances in multiple metabolic pathways including alterations in energy (hyperglycemia, glycogenesis, TCA cycle and lipoprotein biosynthesis), amino acid and nucleic acid metabolism. A mice had hyperglycemia, liver dysfunction, changes in bacterial metabolism and altered gut microbial communities. Moreover, integrative analyses indicated a strong correlation between gut microbiota and host energy metabolism pathways in the liver. Vitamin A regulates host and bacterial metabolism, and the result includes alterations in energy homeostasis. (C) 2017 Elsevier Inc. All rights reserved.
WOS关键词	REGULATORY T-CELLS ; CHAIN FATTY-ACIDS ; RETINOIC ACID ; H-1-NMR SPECTROSCOPY ; OBESITY ; DISEASE ; DIET ; TIME ; DIFFERENTIATION ; COMMUNITIES
WOS研究方向	Biochemistry & Molecular Biology ; Nutrition & Dietetics
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000429504900004
资助机构	American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/12938]
专题	中国科学院武汉物理与数学研究所
通讯作者	Cantorna, Margherita T.
作者单位	1.Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA 2.Univ Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, CAS Key Lab Magnet Resonance Biol Syst,State Key, Wuhan 430071, Hubei, Peoples R China 3.Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
推荐引用方式 GB/T 7714	Tian, Yuan,Nichols, Robert G.,Cai, Jingwei,et al. Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2018,54:28-34.
APA	Tian, Yuan,Nichols, Robert G.,Cai, Jingwei,Patterson, Andrew D.,&Cantorna, Margherita T..(2018).Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,54,28-34.
MLA	Tian, Yuan,et al."Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 54(2018):28-34.