Simultaneous assessment of both lung morphometry and gas exchange function within a single breath-hold by hyperpolarized Xe-129 MRI

doi:10.1002/nbm.3730

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Simultaneous assessment of both lung morphometry and gas exchange function within a single breath-hold by hyperpolarized Xe-129 MRI
	Sun, Xianping 2; Ye, Chaohui 1,2; Zhou, Xin 2; Zhong, Jianping 1,2; Zhang, Huiting 1,2; Ruan, Weiwei 2; Xie, Junshuai 2; Li, Haidong 2; Deng, He 2; Han, Yeqing 2
刊名	NMR IN BIOMEDICINE
	2017-08-01
卷号	30 期号:8
关键词	Cssr Dwcssr Dwi Hyperpolarized Lung Xenon-129
DOI	10.1002/nbm.3730
文献子类	Article
英文摘要	During the measurement of hyperpolarized Xe-129 magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application. Moreover, acquisition during separate breath-holds will increase the measurement error, because of the inconsistent physiological status of the lungs. Here, we present a new method, referred to as diffusion-weighted chemical shift saturation recovery (DWCSSR), in order to perform both DWI and CSSR within a single breath-hold. Compared with sequential single-breath schemes (namely the 'CSSR + DWI' scheme and the 'DWI + CSSR' scheme), the DWCSSR scheme is able to significantly shorten the breath-hold time, as well as to obtain high signal-to-noise ratio (SNR) signals in both DWI and CSSR data. This scheme enables comprehensive information on lung morphometry and function to be obtained within a single breath-hold. In vivo experimental results demonstrate that DWCSSR has great potential for the evaluation and diagnosis of pulmonary diseases.
WOS关键词	HE-3 DIFFUSION MRI ; OF-CONCEPT DEMONSTRATION ; MAGNETIC-RESONANCE ; 129XE MRI ; RAT LUNG ; MODEL ; POLARIZATION ; SPECTROSCOPY ; INJURY ; MICROSTRUCTURE
WOS研究方向	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
语种	英语
WOS记录号	WOS:000405569700007
资助机构	National Natural Science Foundation of China(81227902 ; National Natural Science Foundation of China(81227902 ; National Program for Support of Top-notch Young Professionals ; National Program for Support of Top-notch Young Professionals ; Opening Project of Wuhan National High Magnetic Field Center(2015KF09) ; Opening Project of Wuhan National High Magnetic Field Center(2015KF09) ; 81625011) ; 81625011) ; National Natural Science Foundation of China(81227902 ; National Natural Science Foundation of China(81227902 ; National Program for Support of Top-notch Young Professionals ; National Program for Support of Top-notch Young Professionals ; Opening Project of Wuhan National High Magnetic Field Center(2015KF09) ; Opening Project of Wuhan National High Magnetic Field Center(2015KF09) ; 81625011) ; 81625011)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/11454]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Huazhong Univ Sci & Technol, Sch Phys, Wuhan, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst State,Key Lab, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Sun, Xianping,Ye, Chaohui,Zhou, Xin,et al. Simultaneous assessment of both lung morphometry and gas exchange function within a single breath-hold by hyperpolarized Xe-129 MRI[J]. NMR IN BIOMEDICINE,2017,30(8).
APA	Sun, Xianping.,Ye, Chaohui.,Zhou, Xin.,Zhong, Jianping.,Zhang, Huiting.,...&Han, Yeqing.(2017).Simultaneous assessment of both lung morphometry and gas exchange function within a single breath-hold by hyperpolarized Xe-129 MRI.NMR IN BIOMEDICINE,30(8).
MLA	Sun, Xianping,et al."Simultaneous assessment of both lung morphometry and gas exchange function within a single breath-hold by hyperpolarized Xe-129 MRI".NMR IN BIOMEDICINE 30.8(2017).