Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions

doi:10.1093/nar/gkx025

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions
	Fu, Boshi 3; Zhou, Xiang 3; Wang, Shaoru 3; Li, Conggang 2; Liu, Si-Min 1; Xu, Guohua 2; Wu, Fan 3; Yang, Xi-Ran 1; He, Zhiyong 3; Tian, Tian 3
刊名	NUCLEIC ACIDS RESEARCH
	2017-03-17
卷号	45 期号:5 页码:2283-2293
DOI	10.1093/nar/gkx025
文献子类	Article
英文摘要	Supramolecular chemistry addresses intermolecular forces and consequently promises great flexibility and precision. Biological systems are often the inspirations for supramolecular research. The G-quadruplex (G4) belongs to one of the most important secondary structures in nucleic acids. Until recently, the supramolecular manipulation of the G4 has not been reported. The present study is the first to disclose a supramolecular switch for the reversible control of human telomere G4s. Moreover, this supramolecular switch has been successfully used to manipulate an enzymatic reaction. Using various methods, we show that cucurbit[7] uril preferably locks and encapsulates the positively charged piperidines of Razo through supramolecular interactions. They can switch the conformations of the DNA inhibitor between a flexible state and the rigid G4 and are therefore responsible for the reversible control of the thrombin activity. Thus, our findings open a promising route and exhibit potential applications in future studies of chemical biology.
WOS关键词	DNA G-QUADRUPLEX ; MOLECULAR-RECOGNITION ; NONCOVALENT INTERACTIONS ; SELF-ORGANIZATION ; ORGANIC MATERIALS ; CHEMISTRY ; SYSTEMS ; BINDING ; COMPLEXES ; AFFINITY
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
WOS记录号	WOS:000397286600014
资助机构	National Basic Research Program of China (973 Program)(2012CB720600 ; National Basic Research Program of China (973 Program)(2012CB720600 ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 2012CB720603) ; 2012CB720603) ; 91413109 ; 91413109 ; 21672165 ; 21672165 ; 21372182 ; 21372182 ; 21572169) ; 21572169) ; National Basic Research Program of China (973 Program)(2012CB720600 ; National Basic Research Program of China (973 Program)(2012CB720600 ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 2012CB720603) ; 2012CB720603) ; 91413109 ; 91413109 ; 21672165 ; 21672165 ; 21372182 ; 21372182 ; 21572169) ; 21572169)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/10872]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Wuhan Univ Sci & Technol, Coll Chem Engn & Technol, Wuhan 430081, Hubei Province, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Hubei Province, Peoples R China 3.Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Key Lab Biomed Polymers,Minist Educ, Wuhan 430072, Hubei Province, Peoples R China
推荐引用方式 GB/T 7714	Fu, Boshi,Zhou, Xiang,Wang, Shaoru,et al. Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions[J]. NUCLEIC ACIDS RESEARCH,2017,45(5):2283-2293.
APA	Fu, Boshi.,Zhou, Xiang.,Wang, Shaoru.,Li, Conggang.,Liu, Si-Min.,...&Wang, Jiaqi.(2017).Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions.NUCLEIC ACIDS RESEARCH,45(5),2283-2293.
MLA	Fu, Boshi,et al."Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions".NUCLEIC ACIDS RESEARCH 45.5(2017):2283-2293.