Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines

doi:10.1039/c6ob01191h

	Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines
	You, Y; Wu, ZJ; Wang, ZH; Yuan, WC (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China.; Yuan, WC; Zhang, XM; Xu, XY; Yue, DF
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2016
卷号	14 期号:27 页码:6568-6576
DOI	10.1039/c6ob01191h
产权排序	2
文献子类	Article
英文摘要	An organocatalyzed direct asymmetric vinylogous Michael addition reaction of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines has been developed with a chiral bifunctional amine-squaramide as the catalyst. This approach provides easy access to a series of optically active alpha,beta-unsaturated gamma-substituted butyrolactams in high yields (up to 99%) with excellent diastereoselectivities (up to >99 : 1) and enantio-selectivities (up to >99% ee).
学科主题	Chemistry
语种	英语
资助机构	National Natural Science Foundation of China [21372217, 21572223, 21572224] ; National Natural Science Foundation of China [21372217, 21572223, 21572224] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041] ; National Natural Science Foundation of China [21372217, 21572223, 21572224] ; National Natural Science Foundation of China [21372217, 21572223, 21572224] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/28218]
专题	成都生物研究所_天然产物研究
通讯作者	Yuan, WC (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China.; Xu, XY
推荐引用方式 GB/T 7714	You, Y,Wu, ZJ,Wang, ZH,et al. Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(27):6568-6576.
APA	You, Y.,Wu, ZJ.,Wang, ZH.,Yuan, WC .,Yuan, WC.,...&Yue, DF.(2016).Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines.ORGANIC & BIOMOLECULAR CHEMISTRY,14(27),6568-6576.
MLA	You, Y,et al."Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines".ORGANIC & BIOMOLECULAR CHEMISTRY 14.27(2016):6568-6576.