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	Stimuli-responsive nanoparticles for dual-model imaging guided highly efficient photothermal therapy
	San peng Li; Guanjun Deng; Zhihong Sun; Wenjun Li; Xiaoqing Meng; Ping Gong; Lintao Cai
	2017
会议日期	2017
会议地点	中国北京
英文摘要	The nanomaterials can improve the utilization of the drug and photosensitizer effectively in treating cancer. Continually, the stimuli-responsive nanoparticles have obvious advantages in Theranostic. Herein, we designed GSH/enzyme stimuli-responsive nanoparticles which can differentiate the size and location of tumour with near-infrared optical and photoacoustic imaging. Fistly, IR780-SS was made. Then, HA-SS-IR780 was produced by conjugating targeted hyaluronic acid (HA) and IR780-SS. The molecule HA-SS-IR780 assembled into nanoparticles in PBS. There were some below advantages in those nanoparticles. For one thing, active targeting and EPR effect can improve NPs concentration in the solid tumour. For another thing, the tumor microenvironment (GSH/hyaluronidase) could break fluorescence quenching of IR780, thus, we could distinguish the tumor with normal tissue. Last but not least, the structure of nanoparticle apparently improved the photothermal therapy and reduced the photobleaching of IR780. The analysis of the experiment have certificated the fact that the nanoparticles have a potential biomedical application in dual-model imaging guided highly efficient photothermal therapy.
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12393]
专题	深圳先进技术研究院_医药所
作者单位	2017
推荐引用方式 GB/T 7714	San peng Li,Guanjun Deng,Zhihong Sun,et al. Stimuli-responsive nanoparticles for dual-model imaging guided highly efficient photothermal therapy[C]. 见:. 中国北京. 2017.

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