The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity.

	The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity.
	Mao, Congyang; Xie, Xianzhou; Liu, Xiangmei; Cui, Zhenduo; Yang, Xianjin; Yeung, K. W. K.; Pan, Haobo; Chu, Paul K.; Wu, Shuilin
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2017
文献子类	期刊论文
英文摘要	In this study, we prepared pH-sensitive hybrid nanospheres through the implementation of a facile molecularly imprinted polymer (MIP) technique combined with a UV-initiated precipitation polymerization method using vancomycin (VA) for the templates. During the course of this investigation, both 2-hydroxyethyl methacrylate (HEMA) and 2-(diethylamino) ethyl methacrylate (DEAEMA) were utilized as the functional monomers, while ethylene glycol dimethacrylate (EGDMA) was used as a cross-linker. The obtained MIP nanospheres exhibited well-controlled particle size, with a drug loading capacity of about 17%, much higher than that of the non imprinted polymer (NIP) nanospheres (5%). In addition, the VA loading quantity was closely correlated with the dosage of the cross-linking agent, and the MIP nanospheres exhibited a slower and more controlled VA release rate than the NIP nanospheres. Moreover, these MIP nanosphereswere sensitive to pH values, and consequently showed an increasing release rate of VA as the pH level was decreased. The VA-loaded MIP nanospheresshowed the higher antibacterial ratio of over 92% against Staphylococcus aureus (S. aureus) while the NIP nano spheres were friendly to S. aureus. These MIPnanospheres can be promising for targeting drug delivery system to achieve specific therapies such as preventing bacterial infections and killing cancer cells without damaging health cells and tissues. (C) 2017 Elsevier B.V. All rights reserved.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12363]
专题	深圳先进技术研究院_医药所
作者单位	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
推荐引用方式 GB/T 7714	Mao, Congyang,Xie, Xianzhou,Liu, Xiangmei,et al. The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity.[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017.
APA	Mao, Congyang.,Xie, Xianzhou.,Liu, Xiangmei.,Cui, Zhenduo.,Yang, Xianjin.,...&Wu, Shuilin.(2017).The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity..MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.
MLA	Mao, Congyang,et al."The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity.".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017).