Impaired cerebral autoregulation: measurement and application to stroke.

	Impaired cerebral autoregulation: measurement and application to stroke.
	Xiong, Li; Liu, Xiuyun; Shang, Ty; Smielewski, Peter; Donnelly, Joseph; Guo, Zhen-ni; Yang, Yi; Leung, Thomas; Czosnyka, Marek; Zhang, Rong
刊名	JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
	2017
文献子类	期刊论文
英文摘要	Cerebral autoregulation (CA) is a protective mechanism that maintains cerebral blood flow at a relatively constant level despite fluctuations of cerebral perfusion pressure or arterial blood pressure. It is a universal physiological mechanism that may involve myogenic, neural control as well as metabolic regulations ofcerebral vasculature in response to changes in pressure or cerebral blood flow. Traditionally, CA has been represented by a sigmoid curve with a wide plateau between about 50 mm Hg and 170 mm Hg of steady-state changes in mean arterial pressure, defined as static CA. With the advent of transcranial Doppler,measurement of cerebral blood flow in response to transient changes in arterial pressure has been used to assess dynamic CA. However, a gold standard for measuring CA is not currently available. Stroke has been the leading cause of long-term adult disability throughout the world. A better understanding of CA and its response to pathological derangements can help assess the severity of stroke, guide management decisions, assess response to interventions and provide prognostic information. The objective of this review is to provide a comprehensive insight about physiology of autoregulation, measurement methodologies and clinical applications in stroke to help build a consensus for what should be included in an internationally agreed protocol for CA testing and monitoring, and topromote its translation into clinical bedside practice for stroke management.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12578]
专题	深圳先进技术研究院_数字所
作者单位	JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
推荐引用方式 GB/T 7714	Xiong, Li,Liu, Xiuyun,Shang, Ty,et al. Impaired cerebral autoregulation: measurement and application to stroke.[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,2017.
APA	Xiong, Li.,Liu, Xiuyun.,Shang, Ty.,Smielewski, Peter.,Donnelly, Joseph.,...&Wong, Ka Sing.(2017).Impaired cerebral autoregulation: measurement and application to stroke..JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY.
MLA	Xiong, Li,et al."Impaired cerebral autoregulation: measurement and application to stroke.".JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017).