Linker-free covalent immobilization of heparin, SDF-1 alpha, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation.

	Linker-free covalent immobilization of heparin, SDF-1 alpha, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation.
	Li, Wan ; Gao, Ang ; Hang, Ruiqiang ; Zhang, Wei ; Li, Penghui ; Wang, Guomin ; Bai, Long ; Yu, Xue-Feng ; Wang, Huaiyu ; Tong, Liping
刊名	BIOMATERIALS
	2017
文献子类	期刊论文
英文摘要	Small-diameter vascular grafts made of biomedical polytetrafluoroethylene (PTFE) suffer from the poor long-term patency rate originating from thrombosis and intimal hyperplasia, which can be ascribed to the insufficient endothelialization and chronic inflammation of the materials. Hence, biofunctionalization of PTFEgrafts is highly desirable to circumvent these disadvantages. In this study, a versatile "implantation-incubation" approach in which the biomedical PTFE is initially modified by plasma immersion ion implantation (PHI) is described. After the N-2 PIII treatment, the surface of biomedical PTFE is roughened with nanostructures and more importantly, the abundant free radicals generated underneath the surface continuously migrate to the surface and react with environmental molecules. Taking advantage of this mechanism, various biomolecules with different functions can be steadily immobilized on the surface ofPITE by simple solution immersion. As examples, three typical biomolecules, heparin, SDF-1 alpha, and CD47, are covalently grafted onto the PTFE. In addition to retaining the bioactivity, the surface-functionalized PTFE exhibits reduced thrombogenicity, facilitates the recruitment of endothelial progenitor cells, and even alleviates the inflammatory immune responses of monocytes-macrophages and is thus promising to the development of small-diameter prosthetic vascular grafts with good long-term patency.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12302]
专题	深圳先进技术研究院_医药所
作者单位	BIOMATERIALS
推荐引用方式 GB/T 7714	Li, Wan ,Gao, Ang , Hang, Ruiqiang ,et al. Linker-free covalent immobilization of heparin, SDF-1 alpha, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation.[J]. BIOMATERIALS,2017.
APA	Li, Wan .,Gao, Ang ., Hang, Ruiqiang ., Zhang, Wei ., Li, Penghui .,...& Chu, Paul K..(2017).Linker-free covalent immobilization of heparin, SDF-1 alpha, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation..BIOMATERIALS.
MLA	Li, Wan ,et al."Linker-free covalent immobilization of heparin, SDF-1 alpha, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation.".BIOMATERIALS (2017).