NK Cell exhaustion.

	NK Cell exhaustion.
	Tian, Zhigang; Bi, Jiacheng
刊名	FRONTIERS IN IMMUNOLOGY
	2017
文献子类	期刊论文
英文摘要	Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustion of NK cells, such as dysregulated NK cell receptors signaling, as well as suppressive effects by regulatory cells or soluble factors within the microenvironment. Better understanding of the characteristics, as well as the underlying mechanisms of NK cell exhaustion, not only should increase our understanding of the basic biology of NK cells but also could reveal novel NK cell-based antitumor/infection targets. Here, we provide an overview of our current knowledge on NK cell exhaustion in tumors, and in chronic infections.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12283]
专题	深圳先进技术研究院_医药所
作者单位	FRONTIERS IN IMMUNOLOGY
推荐引用方式 GB/T 7714	Tian, Zhigang,Bi, Jiacheng. NK Cell exhaustion.[J]. FRONTIERS IN IMMUNOLOGY,2017.
APA	Tian, Zhigang,&Bi, Jiacheng.(2017).NK Cell exhaustion..FRONTIERS IN IMMUNOLOGY.
MLA	Tian, Zhigang,et al."NK Cell exhaustion.".FRONTIERS IN IMMUNOLOGY (2017).