Regulation of NF-kappa B by PML and PML-RAR alpha.

	Regulation of NF-kappa B by PML and PML-RAR alpha.
	Lindsay AJ; Ahmed A; Wan X; Mitxitorena I; Paolo Pandolfi P; McCaffrey MW; Keeshan K; Chen YH; Carmody RJ
刊名	Scientific Reports
	2017
文献子类	期刊论文
英文摘要	Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation. We demonstrate that PML promotes TNFα-induced transcriptional responses by promoting NF-κB activity. TNFα-treated PML−/− cells show normal IκBα degradation and NF-κB nuclear translocation but significantly reduced NF-κB DNA binding and phosphorylation of NF-κB p65. We also demonstrate that the PML retinoic acid receptor-α (PML-RARα) oncofusion protein, which causes acute promyelocytic leukemia, inhibits TNFα induced gene expression and phosphorylation of NF-κB. This study establishes PML as an important regulator of NF-κB and demonstrates that PML-RARα dysregulates NF-κB.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12278]
专题	深圳先进技术研究院_医药所
作者单位	Scientific Reports
推荐引用方式 GB/T 7714	Lindsay AJ,Ahmed A,Wan X,et al. Regulation of NF-kappa B by PML and PML-RAR alpha.[J]. Scientific Reports,2017.
APA	Lindsay AJ.,Ahmed A.,Wan X.,Mitxitorena I.,Paolo Pandolfi P.,...&Carmody RJ.(2017).Regulation of NF-kappa B by PML and PML-RAR alpha..Scientific Reports.
MLA	Lindsay AJ,et al."Regulation of NF-kappa B by PML and PML-RAR alpha.".Scientific Reports (2017).