Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment and Real-time Monitoring Based on Fluorescence Resonance Energy Transfer

	Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment and Real-time Monitoring Based on Fluorescence Resonance Energy Transfer
	Sheng, Zonghai ; Cui, Haodong ; Hu, Dehong ; Zhang, Jingnan ; Gao, Guanhui ; Chen, Ze ; Li, Wenjun ; Gong, Ping ; Cai, Lintao
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
文献子类	期刊论文
英文摘要	Well-designed gold nanoclusters−indocyanine green nanoprobes (Au NCs−INPs) have been developed by the conjugation of Au NC assemblies with indocyanine green (ICG) for the therapeutic real-time monitoring based on fluorescence resonance energy transfer (FRET). The synthesized Au NCs−INPs demonstrated the improved cellular uptake and effective tumor targeting because of the enhanced permeability and retention effect and the gp60-mediated secreted protein acidic and rich in cysteine combined transport pathway, suggesting excellent dual-modal near-infrared fluorescence and photoacoustic imaging. Moreover, the simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT) of Au NCs−INPs exhibited higher cancer cell killing and tumor removal efficiency than those of PDT or PTT alone. More importantly, a promising therapeutic monitoring strategy was performed based on FRET between Au NCs and ICG, suggesting that Au NCs−INPs could be utilized to evaluate the therapeutic response by real-time monitoring the change in Au NCs in fluorescence intensity together with ICG supersession. Therefore, Au NCs−INPs as a novel photosensitizer have great potentials for combined tumor imaging, therapy, and therapeutic monitoring in real time.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12263]
专题	深圳先进技术研究院_医药所
作者单位	ACS APPLIED MATERIALS & INTERFACES
推荐引用方式 GB/T 7714	Sheng, Zonghai ,Cui, Haodong , Hu, Dehong ,et al. Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment and Real-time Monitoring Based on Fluorescence Resonance Energy Transfer[J]. ACS APPLIED MATERIALS & INTERFACES,2017.
APA	Sheng, Zonghai .,Cui, Haodong ., Hu, Dehong ., Zhang, Jingnan ., Gao, Guanhui .,...& Cai, Lintao.(2017).Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment and Real-time Monitoring Based on Fluorescence Resonance Energy Transfer.ACS APPLIED MATERIALS & INTERFACES.
MLA	Sheng, Zonghai ,et al."Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment and Real-time Monitoring Based on Fluorescence Resonance Energy Transfer".ACS APPLIED MATERIALS & INTERFACES (2017).