Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy

	Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy
	Dapeng Ni; Xiaoqing Meng; Yueting Yang; Lihua Zhou; li Zhang; Yalin Lv; Sanpeng Li; Yayun Wu; Mingbin Zheng; Wenjun Li
刊名	Theranostics
	2017
文献子类	期刊论文
英文摘要	The precision oncology significantly relies on the development of multifunctional agents to integrate tumor targeting, imaging and therapeutics. In this study, a first small-molecule theranostic probe, RhoSSCy is constructed by conjugating 5′-carboxyrhodamines (Rho) and heptamethine cyanine IR765 (Cy) using a reducible disulfide linker and pH tunable amino-group to realize thiols/pH dual sensing. In vitro experiments verify that RhoSSCy is highly sensitive for quantitative analysis and imaging intracellular pH gradient and biothiols. Furthermore, RhoSSCy shows superb tumor targeted dual-modal imaging via near-infrared fluorescence (NIRF) and photoacoustic (PA). Importantly, RhoSSCy also induces strongly reactive oxygen species for tumor photodynamic therapy (PDT) with robust antitumor activity both in vitro and in vivo. Such versatile small-molecule theranostic probe may be promising for tumor targeted imaging and precision therapy.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12255]
专题	深圳先进技术研究院_医药所
作者单位	Theranostics
推荐引用方式 GB/T 7714	Dapeng Ni,Xiaoqing Meng,Yueting Yang,et al. Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy[J]. Theranostics,2017.
APA	Dapeng Ni.,Xiaoqing Meng.,Yueting Yang.,Lihua Zhou.,li Zhang.,...&Lintao Cai.(2017).Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy.Theranostics.
MLA	Dapeng Ni,et al."Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy".Theranostics (2017).