Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo.

	Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo.
	Zhang, Jinfeng; Zhang, Jun; Li, Wenyue; Chen, Rui; Zhang, Zhenyu; Zhang, Wenjun; Tang, Yongbing; Chen, Xiaoyuan; Liu, Gang; Lee, Chun-Sing
刊名	THERANOSTICS
	2017
文献子类	期刊论文
英文摘要	The development of nanoscaled theranostic agents for cancer combination therapies has received intensive attention in recent years. In this report, adegradable hollow mesoporous PEG-Si/C-DOX NP is designed and fabricated for pH-responsive, photoacoustic imaging-guided highly effective chemo-thermalcombination therapy. The intrinsic hollow mesoporous structure endows the as-synthesized nanoparticles (NPs) with a high drug loading capacity (31.1%). Under NIR (808 nm) irradiation, the photothermal conversion efficiency of the Si/C NPs is as high as 40.7%. Preferential accumulation of the PEG-Si/C-DOX NPs around tumor tissue was demonstrated with photoacoustic images. Cellular internalization of the NPs and release of the DOX in nuclei are shown with fluorescent images. With efficient NIR photothermal conversion and high DOX loading capacity, the PEG-Si/C-DOX NPs are demonstrated to have remarkable cancer-cell-killing ability and to achieve complete in vivo tumor elimination via combinational chemo-thermal therapy. Last but not least, the NPs show good biodegradability and biosafety, making them a promising candidate for multifunctional drug delivery and cancer theranostic.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/11747]
专题	深圳先进技术研究院_集成所
作者单位	THERANOSTICS
推荐引用方式 GB/T 7714	Zhang, Jinfeng,Zhang, Jun,Li, Wenyue,et al. Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo.[J]. THERANOSTICS,2017.
APA	Zhang, Jinfeng.,Zhang, Jun.,Li, Wenyue.,Chen, Rui.,Zhang, Zhenyu.,...&Lee, Chun-Sing.(2017).Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo..THERANOSTICS.
MLA	Zhang, Jinfeng,et al."Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo.".THERANOSTICS (2017).