Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems

doi:10.1021/acsami.7b05383

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems
	Wang, T; Wang, L; Li, XM; Hu, XJ; Han, YP; Luo, Y; Wan, ZJ; Li, Q; Aldalbahi, A; Wang, LH
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
卷号	9 期号:22 页码:18619-18625
关键词	Graphene Oxide Nanosheets Engineered Nanoparticles Cellular Uptake Conjugated Polymer Endothelial-cells Endocytosis Mechanisms Entry Cytotoxicity Exocytosis
ISSN号	1944-8244
DOI	10.1021/acsami.7b05383
文献子类	期刊论文
英文摘要	Nanopartides (NPs) have ahowia great promise as intracellular imaging probes or nanocarriers and are increasingly being used in biomedical applications. A detailed understanding of how NPs get "in and our of cells is important for developing new nanomkterials with improved selectivity and less cytotoxicify. Both cellular and chemical characteristics have been proven to regulate the cellular uptake of NPs. However, the exocytosis Ness and its regulation are less explored. Herein, we investigated the size-regulated endocytosis and exocytosis of carboxylated polystyrene (PS). NPs, PS NPs with a smaller site were endocytosed mainly through the clathrin-dependent pathlway, whereas PS NPs with a larger size preferred caveolae-mediated endocytosis, Furthermore, our results revealed exocytosis of larger PS NPs and tracked the dynamic process at the single-particle level. These results a indicate that particle size is a key factor for the regulation intracellular trafficking of NPs and provide new insight into the :development of more effective cellular nanocarriers.
WOS关键词	GRAPHENE OXIDE NANOSHEETS ; ENGINEERED NANOPARTICLES ; CELLULAR UPTAKE ; CONJUGATED POLYMER ; ENDOTHELIAL-CELLS ; ENDOCYTOSIS ; MECHANISMS ; ENTRY ; CYTOTOXICITY ; EXOCYTOSIS
语种	英语
WOS记录号	WOS:000403136400026
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/28820]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wang, T,Wang, L,Li, XM,et al. Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18619-18625.
APA	Wang, T.,Wang, L.,Li, XM.,Hu, XJ.,Han, YP.,...&Chen, N.(2017).Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems.ACS APPLIED MATERIALS & INTERFACES,9(22),18619-18625.
MLA	Wang, T,et al."Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18619-18625.