Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides

doi:10.1021/acsami.7b08732

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides
	Lu, N; Wen, YL; Liu, G; Ding, L; Zeng, CX; Aldalbahi, A; Khan, MN; Periyasami, G; Rahaman, M; Alrohaili, A
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
卷号	9 期号:36 页码:30406-30413
关键词	Unmodified Gold Nanoparticles In-vivo Colorimetric Detection Drug-delivery Magnetic Nanoparticles Carbon Nanotubes Graphene Oxide Porous Shells Quantum Dots Label-free
ISSN号	1944-8244
DOI	10.1021/acsami.7b08732
文献子类	期刊论文
英文摘要	The excellent performance of a biosensor generally depends on the high signal-to-noise ratio, and the superquencher plays a dominant role in fluorescent sensors. Novel nanoquenchers exhibited high quenching efficiency in various fluorescent assays of biological/chemical molecules. Here, we developed a novel nano-biosensor using Fe3O4@C yolk-shell nanoparticles (YSNPs) and studied their quenching effect. We found Fe3O4@C YSNP was a superquencher and exhibited an ultrastrong quenching ability, up to almost 100% quenching efficiency, toward fluorophores. Also, Fe3O4@C YSNPs possessed the most superior fluorescence restoration efficiency, due to biomolecular recognition event, compared to the other nanoquenchers, including bare Fe3O4 NPs, graphene oxide (GO), and single-wall carbon nanotubes (SWCNTs). On the basis of that, a fluorescent sensing platform for potassium-ion (K+) analysis with guanine (G)-rich oligonucleotides was designed. As a result, Fe3O4@C YSNP-based fluorescent sensors demonstrated excellent performance, with an ultrahigh sensitivity of a detection limit as low as 1.3 mu M, as well as a wide dynamic range from 50 mu M to 10 mM. The proposed method is fast, simple, and cost-effective, suggesting the great potential for practical applications in biomedical detection and clinical diagnosis.
WOS关键词	UNMODIFIED GOLD NANOPARTICLES ; IN-VIVO ; COLORIMETRIC DETECTION ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; GRAPHENE OXIDE ; POROUS SHELLS ; QUANTUM DOTS ; LABEL-FREE
语种	英语
WOS记录号	WOS:000411043600019
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/28742]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Lu, N,Wen, YL,Liu, G,et al. Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(36):30406-30413.
APA	Lu, N.,Wen, YL.,Liu, G.,Ding, L.,Zeng, CX.,...&Zhang, M.(2017).Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides.ACS APPLIED MATERIALS & INTERFACES,9(36),30406-30413.
MLA	Lu, N,et al."Multifunctional Yolk-Shell Nanostructure as a Superquencher for Fluorescent Analysis of Potassium Ion Using Guanine-Rich Oligonucleotides".ACS APPLIED MATERIALS & INTERFACES 9.36(2017):30406-30413.