Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation

doi:10.1038/nchem.2852

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation
	Li, J; Green, AA; Yan, H; Fan, CH
刊名	NATURE CHEMISTRY
	2017
卷号	9 期号:11 页码:1056-1067
关键词	Tetrahedral Dna Nanostructure Strand Displacement Cascades Hybridization Chain-reaction Green Fluorescent Protein Synthetic Biology Gene-expression Drug-delivery Logic Gates Mammalian-cells Living Cells
ISSN号	1755-4330
DOI	10.1038/nchem.2852
文献子类	期刊论文
英文摘要	Nucleic acids have attracted widespread attention due to the simplicity with which they can be designed to form discrete structures and programmed to perform specific functions at the nanoscale. The advantages of DNA/RNA nanotechnology offer numerous opportunities for in-cell and in-vivo applications, and the technology holds great promise to advance the growing field of synthetic biology. Many elegant examples have revealed the potential in integrating nucleic acid nanostructures in cells and in vivo where they can perform important physiological functions. In this Review, we summarize the current abilities of DNA/RNA nanotechnology to realize applications in live cells and then discuss the key problems that must be solved to fully exploit the useful properties of nanostructures. Finally, we provide viewpoints on how to integrate the tools provided by DNA/RNA nanotechnology and related new technologies to construct nucleic acid nanostructure-based molecular circuitry for synthetic biology.
WOS关键词	TETRAHEDRAL DNA NANOSTRUCTURE ; STRAND DISPLACEMENT CASCADES ; HYBRIDIZATION CHAIN-REACTION ; GREEN FLUORESCENT PROTEIN ; SYNTHETIC BIOLOGY ; GENE-EXPRESSION ; DRUG-DELIVERY ; LOGIC GATES ; MAMMALIAN-CELLS ; LIVING CELLS
语种	英语
WOS记录号	WOS:000413569500006
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/28641]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Li, J,Green, AA,Yan, H,et al. Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation[J]. NATURE CHEMISTRY,2017,9(11):1056-1067.
APA	Li, J,Green, AA,Yan, H,&Fan, CH.(2017).Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.NATURE CHEMISTRY,9(11),1056-1067.
MLA	Li, J,et al."Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation".NATURE CHEMISTRY 9.11(2017):1056-1067.