Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo

doi:10.1002/ppsc.201600208

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo
	Yi, HY; Li, XJ; Wang, ZY; Yin, M; Wang, LH; Aldalbahi, A; El-Sayed, NN; Wang, H; Chen, N; Chen, LN
刊名	PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
	2017
卷号	34 期号:1 页码:-
关键词	Cancer Cell Migration Embryonic Development Nanodiamonds Obesity Signal Transduction
ISSN号	0934-0866
DOI	10.1002/ppsc.201600208
文献子类	期刊论文
英文摘要	Biocompatible nanoparticles hold a great promise for biomedical applications, whereas their biosafety has raised extensive concerns. Nanodiamonds (NDs) are generally regarded as inert nanocarriers and widely employed in biomedical studies; however, it is yet to explore their biological effects in more general contexts. In this study, the authors observe that intracellular NDs block signal transduction of the Wnt signaling pathway, an effect that is not caused by general cytotoxicity. The authors find that NDs attenuate activities of Wnt signaling in several types of cell lines and in Zebrafish, and interfere with Wnt signaling-controlled biological processes, including cancer cell migration, adipocyte differentiation, and embryonic development. Significantly, the authors show that intracellular NDs trigger degradation of the disheveled protein, a key component of Wnt signaling cascade, while they do not affect protein stability of other Wnt signal transducers or other signaling molecules. This work thus illustrates a novel crosstalk between nanoparticles and the Wnt signaling pathway, and expands the understanding of biological effects induced by nanoparticles. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, this study also provides the rationale for potential applications of NDs in cancer therapies.
语种	英语
WOS记录号	WOS:000393580600007
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/27391]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Yi, HY,Li, XJ,Wang, ZY,et al. Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2017,34(1):-.
APA	Yi, HY.,Li, XJ.,Wang, ZY.,Yin, M.,Wang, LH.,...&Song, HY.(2017).Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,34(1),-.
MLA	Yi, HY,et al."Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 34.1(2017):-.