Selective recognition of specific G-quadruplex vs. duplex DNA by a phenanthroline derivative

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	Selective recognition of specific G-quadruplex vs. duplex DNA by a phenanthroline derivative
	Zhang, Hong; Xiang, Junfeng; Hu, Haiyu; Liu, Yan; Yang, Fengmin; Shen, Gang; Tang, Yalin; Chen, Chuanfeng
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2015-07-01
卷号	78 页码:149-156
英文摘要	A key problem in designing G-quadruplex ligand is how to discriminate quadruplex DNA specifically from other DNAs, searching ligands targeted at special G-quadruplex structure with high selectivity is a major challenge. Herein, a phenanthrolin-dicarboxylate ester (PD) is proved to exhibit selectivity toward parallel and hybrid G-quadruplex structures with propeller and edge-wise loops, over duplex DNA and antiparallel quadruplex structure with diagonal loop. Such preferred binding of PD to these special G-quadruplex structures is possibly resulted from steric hindrance of: (1) the four substituent groups in PD molecule which prevent close interaction with duplex DNA and (2) the diagonal loop above the G-tetrads in antiparallel G-quadruplex which hinder face-to-face stacking of planar phenanthrolin ring to G-tetrads. In line with its stabilizing ability of G-quadruplex, PD molecule exhibit a inhibitory ability telomerase activity, as well as the potent cytotoxic activity against several human cancer cell lines, which makes it an interesting anti-tumor drug lead. (C) 2015 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38673]
专题	化学研究所_其它
推荐引用方式 GB/T 7714	Zhang, Hong,Xiang, Junfeng,Hu, Haiyu,et al. Selective recognition of specific G-quadruplex vs. duplex DNA by a phenanthroline derivative[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2015,78:149-156.
APA	Zhang, Hong.,Xiang, Junfeng.,Hu, Haiyu.,Liu, Yan.,Yang, Fengmin.,...&Chen, Chuanfeng.(2015).Selective recognition of specific G-quadruplex vs. duplex DNA by a phenanthroline derivative.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,78,149-156.
MLA	Zhang, Hong,et al."Selective recognition of specific G-quadruplex vs. duplex DNA by a phenanthroline derivative".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 78(2015):149-156.