Improved and optimized one-pot method for N-succinimidyl-4-[F-18] fluorobenzoate ([F-18]SFB) synthesis using microwaves

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	Improved and optimized one-pot method for N-succinimidyl-4-[F-18] fluorobenzoate ([F-18]SFB) synthesis using microwaves
	Li, Kang-Po; Hu, Ming-Kuan; Shen, Clifton Kwang-Fu; Lin, Wei-Yu; Hou, Shuang; Zhao, Li-Bo; Cheng, Cheng-Yi; Shen, Daniel. H.
刊名	APPLIED RADIATION AND ISOTOPES
	2014-12-01
卷号	94 页码:113-117
英文摘要	Chemoselective control over N/Oselectivity is an intriguing issue in nitroso chemistry. Recently, we reported an unprecedented asymmetric -amination reaction of -ketocarbonyl compounds that proceeded through the catalytic coupling of enamine carbonyl groups with in-situ-generated carbonyl nitroso moieties. This process was facilitated by a simple chiral primary and tertiary diamine that was derived from tert-leucine. This reaction featured high chemoselectivity and excellent enantioselectivity for a broad range of substrates. Herein, a computational study was performed to elucidate the origins of the enantioselectivity and N/Oregioselectivity. We found that a bidentate hydrogen-bonding interaction between the tertiary N+H and nitrosocarbonyl groups accounted for the high Nselectivity, whilst the enantioselectivity was determined by Si-facial attack on the (E)- and (Z)-enamines in a Curtin-Hammett-type manner. The bidentate hydrogen-bonding interaction with the nitrosocarbonyl moieties reinforced the facial selectivity in this process.
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38610]
专题	化学研究所_其它
推荐引用方式 GB/T 7714	Li, Kang-Po,Hu, Ming-Kuan,Shen, Clifton Kwang-Fu,et al. Improved and optimized one-pot method for N-succinimidyl-4-[F-18] fluorobenzoate ([F-18]SFB) synthesis using microwaves[J]. APPLIED RADIATION AND ISOTOPES,2014,94:113-117.
APA	Li, Kang-Po.,Hu, Ming-Kuan.,Shen, Clifton Kwang-Fu.,Lin, Wei-Yu.,Hou, Shuang.,...&Shen, Daniel. H..(2014).Improved and optimized one-pot method for N-succinimidyl-4-[F-18] fluorobenzoate ([F-18]SFB) synthesis using microwaves.APPLIED RADIATION AND ISOTOPES,94,113-117.
MLA	Li, Kang-Po,et al."Improved and optimized one-pot method for N-succinimidyl-4-[F-18] fluorobenzoate ([F-18]SFB) synthesis using microwaves".APPLIED RADIATION AND ISOTOPES 94(2014):113-117.