Methylation of C(sp(3))-H/C(sp(2))-H Bonds with Methanol Catalyzed by Cobalt System

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	Methylation of C(sp(3))-H/C(sp(2))-H Bonds with Methanol Catalyzed by Cobalt System
	Liu, Zhenghui 1,2; Yang, Zhenzhen 1; Yu, Xiaoxiao 1,2; Zhang, Hongye 1; Yu, Bo 1; Zhao, Yanfei 1; Liu, Zhimin 1,2
刊名	ORGANIC LETTERS
	2017-10-06
卷号	19 期号:19 页码:5228-5231
英文摘要	A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand P(CH2CH2PPh2)(3)(PP3), and a base (denoted as [Co]/PP3/base), is developed for the methylation of C(sp(3))-H and C(sp(2))-H bonds using methanol as a methylating reagent. The Co(BF4)(2)center dot 6H(2)O/PP3/K2CO3 catalytic system showed high catalytic activity for the methylation of C-H bonds in aryl alkyl ketones, aryl acetonitriles, and indoles, with wide substrate scope and good functional group tolerance, and methyl-substituted products were obtained in good to excellent yields at 100 degrees C. This cheap, readily available, and highly efficient Co-based catalytic system may have promising applications in methylation reaction using methanol.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/41282]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Colloid Interface & Thermodynam, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhenghui,Yang, Zhenzhen,Yu, Xiaoxiao,et al. Methylation of C(sp(3))-H/C(sp(2))-H Bonds with Methanol Catalyzed by Cobalt System[J]. ORGANIC LETTERS,2017,19(19):5228-5231.
APA	Liu, Zhenghui.,Yang, Zhenzhen.,Yu, Xiaoxiao.,Zhang, Hongye.,Yu, Bo.,...&Liu, Zhimin.(2017).Methylation of C(sp(3))-H/C(sp(2))-H Bonds with Methanol Catalyzed by Cobalt System.ORGANIC LETTERS,19(19),5228-5231.
MLA	Liu, Zhenghui,et al."Methylation of C(sp(3))-H/C(sp(2))-H Bonds with Methanol Catalyzed by Cobalt System".ORGANIC LETTERS 19.19(2017):5228-5231.