Selective Imaging and Inactivation of Bacteria over Mammalian Cells by Imidazolium-Substituted Polythiophene

	Selective Imaging and Inactivation of Bacteria over Mammalian Cells by Imidazolium-Substituted Polythiophene
	Huang, Yun 1,3; Pappas, Harry C.2; Zhang, Liqin 3; Wang, Shanshan 3; Ca, Ren 3; Tan, Weihong 3; Wang, Shu 4; Whitten, David G.2; Schanze, Kirk S.1
刊名	CHEMISTRY OF MATERIALS
	2017-08-08
卷号	29 期号:15 页码:6389-6395
英文摘要	Antibiotic-resistant bacterial infections have become a serious public health threat. In an effort to address this threat, we develop an imidazolium-functionalized conjugated polyelectrolyte that exhibits profound light-activated biocidal activity. Here we report the synthesis, photophysical properties, and biocidal activity of a regioregular head-to-tail polythiophene substituted with cationic imidazolium units (P3HT-Im) prepared by Grignard metathesis controlled polymerization. In water, P3HT-Im has a broad absorption in the visible region and exhibited a remarkably high biocidal efficiency with both Gram-positive and Gram-negative bacteria at sub-microgram per milliliter concentrations. Moreover, mammalian cell studies suggest that P3HT-Im is nontoxic to mammalian cells at concentrations of <= 20 mu g/mL over a short time scale (<= 1 h) in the dark and light, and the targeting rate-dependent selective mechanism is revealed. This Study demonstrates the capability of P3HT-Im to achieve selective imaging and inactivation of bacteria over mammalian cells, suggesting that the polymer has significant potential for ameliorating antibiotic-resistant bacteria in a clinical setting.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39291]
专题	化学研究所_有机固体实验室
作者单位	1.Univ Texas San Antonio, Dept Chem, One UTSA Circle, San Antonio, TX 78249 USA 2.Univ New Mexico, Dept Chem & Biol Engn, Albuquerque, NM 87131 USA 3.Univ Florida, Dept Chem, Gainesville, FL 32611 USA 4.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Huang, Yun,Pappas, Harry C.,Zhang, Liqin,et al. Selective Imaging and Inactivation of Bacteria over Mammalian Cells by Imidazolium-Substituted Polythiophene[J]. CHEMISTRY OF MATERIALS,2017,29(15):6389-6395.
APA	Huang, Yun.,Pappas, Harry C..,Zhang, Liqin.,Wang, Shanshan.,Ca, Ren.,...&Schanze, Kirk S..(2017).Selective Imaging and Inactivation of Bacteria over Mammalian Cells by Imidazolium-Substituted Polythiophene.CHEMISTRY OF MATERIALS,29(15),6389-6395.
MLA	Huang, Yun,et al."Selective Imaging and Inactivation of Bacteria over Mammalian Cells by Imidazolium-Substituted Polythiophene".CHEMISTRY OF MATERIALS 29.15(2017):6389-6395.