In vivo study of a bioactive nanoparticle-gelatin composite scaffold for bone defect repair in rabbits

	In vivo study of a bioactive nanoparticle-gelatin composite scaffold for bone defect repair in rabbits
	Hou, Guojin 1; Zhou, Fang 1; Guo, Yan 1; Yang, Zhongwei 1; Li, Ailing 1,2; Wang, Chen 2; Qiu, Dong 2
刊名	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
	2017-11-01
卷号	28 期号:11
英文摘要	The purpose is to study the in vivo bioactivity of this scaffold and verify its ability to simulate the characteristics of cancellous bone. Twenty-four adult New Zealand white rabbits were divided into three groups. Bone defects above the femoral condylar of both sides were created. A newly designed bioactive nanoparticle-gelatin composite scaffold was implanted to the experimental side, while the control side was left without implantation. The repair of bone defect was monitored by X-ray examination, gross observation, Micro-CT examination and histological observation of the area of bone defect 4, 8 and 12 weeks after surgery. There was void of new bone tissue in medullary cavity in the bone defect area of the control side. In the experimental side, the composite scaffold displayed excellent biodegradability, bioactivity and cytocompatibility. With the time laps, new bone tissue grew from the edge to center as revealed by both Micro-CT image and staining biopsy, which complies with the "creeping substitution" process. The mechanical properties of the newly designed bioactive nanoparticle-gelatin composite scaffold and the 3-D structure of new bone tissue are comparable to the surrounding cancellous bones. This newly developed bioactive nanoparticle-gelatin composite scaffold possesses good biocompatibility and in vivo osteogenic capability for bone defect repair. It may be a promising artificial bone grafts.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39168]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Peking Univ, Hosp 3, Dept Orthopaed Surg, 49 North Garden Rd, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Hou, Guojin,Zhou, Fang,Guo, Yan,et al. In vivo study of a bioactive nanoparticle-gelatin composite scaffold for bone defect repair in rabbits[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2017,28(11).
APA	Hou, Guojin.,Zhou, Fang.,Guo, Yan.,Yang, Zhongwei.,Li, Ailing.,...&Qiu, Dong.(2017).In vivo study of a bioactive nanoparticle-gelatin composite scaffold for bone defect repair in rabbits.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,28(11).
MLA	Hou, Guojin,et al."In vivo study of a bioactive nanoparticle-gelatin composite scaffold for bone defect repair in rabbits".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 28.11(2017).