Lactate-Based Ionic Liquid Catalyzed Reductive Amination/Cyclization of Keto Acids under Mild Conditions: A Metal-Free Route To Synthesize Lactams

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	Lactate-Based Ionic Liquid Catalyzed Reductive Amination/Cyclization of Keto Acids under Mild Conditions: A Metal-Free Route To Synthesize Lactams
	Wu, Cailing 1,2; Zhang, Hongye 1; Yu, Bo 1; Chen, Yu 1,2; Ke, Zhengang 1,2; Guo, Shien 1,2; Liu, Zhimin 1,2
刊名	ACS CATALYSIS
	2017-11-01
卷号	7 期号:11 页码:7772-7776
关键词	Biomass Levulinic Acid Reductive Amination Ionic Liquid Lactams Conversion
英文摘要	Task-specific ionic liquids (ILs) have shown promising applications in catalysis. Herein we present lactate based IL (e.g., 1-butyl-3-methylimidazolium lactate, [BMIm][Lac]) catalyzed reductive amination/cyclization of keto acids using triethoxysilane as a reducing agent, which provides a metal-free route to synthesis of lactams under mild conditions, even at room temperature. [BMIm][Lac] combined with (EtO)(3)SiH afforded a series of five- and six-membered lactams in good to excellent yields at 80 degrees C within 1 h, showing comparable performance to the best metal-based catalyst reported to date. The mechanism investigation indicated that the ILs (e.g., [BMIm][Lac]) served as a multifunctional catalyst, which could activate hydrosilanes and simultaneously catalyzed the cyclization of LA with amines.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39154]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Colloid Interface & Thermodynam, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Cailing,Zhang, Hongye,Yu, Bo,et al. Lactate-Based Ionic Liquid Catalyzed Reductive Amination/Cyclization of Keto Acids under Mild Conditions: A Metal-Free Route To Synthesize Lactams[J]. ACS CATALYSIS,2017,7(11):7772-7776.
APA	Wu, Cailing.,Zhang, Hongye.,Yu, Bo.,Chen, Yu.,Ke, Zhengang.,...&Liu, Zhimin.(2017).Lactate-Based Ionic Liquid Catalyzed Reductive Amination/Cyclization of Keto Acids under Mild Conditions: A Metal-Free Route To Synthesize Lactams.ACS CATALYSIS,7(11),7772-7776.
MLA	Wu, Cailing,et al."Lactate-Based Ionic Liquid Catalyzed Reductive Amination/Cyclization of Keto Acids under Mild Conditions: A Metal-Free Route To Synthesize Lactams".ACS CATALYSIS 7.11(2017):7772-7776.