Biofluid-Triggered Burst Release from an Adaptive Covalently Assembled Dipeptide Nanocontainer for Emergency Treatment

CORC > 化学研究所 > 中国科学院化学研究所 > 胶体、界面与化学热力学实验室

	Biofluid-Triggered Burst Release from an Adaptive Covalently Assembled Dipeptide Nanocontainer for Emergency Treatment
	Fei, Jinbo 1; Zhang, He 1,2; Wang, Anhe 3; Qin, Chenchen 1,2; Xue, Huimin 1,2; Li, Junbai 1,2
刊名	ADVANCED HEALTHCARE MATERIALS
	2017-04-05
卷号	6 期号:7
英文摘要	The construction of quickly dissociating containers holding bioactive components that meet the extreme requirements of emergency treatment is highly desirable but remains a great challenge. Here the use of small-molecule-induced dynamic covalent assembly is reported for simple and tunable fabrication of a biocompatible diphenylalanine-based nanocontainer toward rapidly responsive cargo delivery. The assembled nanocontainer can adaptively encapsulate various charged or neutral molecules. Upon biofluid trigger, the encapsulated molecules and bioactive proteins are released in a burst (within 5 s) from the nanocontainer due to highly sensitive deprotonation-mediated disruption of hydrogen bonding. This highlighted feature allows the nanocontainer as an excellent "fast dissolving" delivery vehicle available in spray dosage form for medical emergencies, as demonstrated by in vivo application for massive hemorrhage.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39036]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Fei, Jinbo,Zhang, He,Wang, Anhe,et al. Biofluid-Triggered Burst Release from an Adaptive Covalently Assembled Dipeptide Nanocontainer for Emergency Treatment[J]. ADVANCED HEALTHCARE MATERIALS,2017,6(7).
APA	Fei, Jinbo,Zhang, He,Wang, Anhe,Qin, Chenchen,Xue, Huimin,&Li, Junbai.(2017).Biofluid-Triggered Burst Release from an Adaptive Covalently Assembled Dipeptide Nanocontainer for Emergency Treatment.ADVANCED HEALTHCARE MATERIALS,6(7).
MLA	Fei, Jinbo,et al."Biofluid-Triggered Burst Release from an Adaptive Covalently Assembled Dipeptide Nanocontainer for Emergency Treatment".ADVANCED HEALTHCARE MATERIALS 6.7(2017).