Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration

	Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration
	Zhang, Jian 1,2; Jia, Jinpeng 3; Kim, Jimin P.4; Shen, Hong 1; Yang, Fei 1,2; Zhang, Qiang 3; Xu, Meng 3; Bi, Wenzhi 3; Wang, Xing 1; Yang, Jian 4
刊名	ADVANCED MATERIALS
	2017-05-03
卷号	29 期号:17
英文摘要	Inspired by the highly ordered nanostructure of bone, nanodopant composite biomaterials are gaining special attention for their ability to guide bone tissue regeneration through structural and biological cues. However, bone malformation in orthopedic surgery is a lingering issue, partly due to the high surface energy of traditional nanoparticles contributing to aggregation and inhomogeneity. Recently, carboxyl-functionalized synthetic polymers have been shown to mimic the carboxyl-rich surface motifs of non-collagenous proteins in stabilizing hydroxyapatite and directing intrafibrillar mineralization in-vitro. Based on this biomimetic approach, it is herein demonstrated that carboxyl functionalization of poly(lactic-co-glycolic acid) can achieve great material homogeneity in nanocomposites. This ionic colloidal molding method stabilizes hydroxyapatite precursors to confer even nanodopant packing, improving therapeutic outcomes in bone repair by remarkably improving mechanical properties of nanocomposites and optimizing controlled drug release, resulting in better cell in-growth and osteogenic differentiation. Lastly, better controlled biomaterial degradation significantly improved osteointegration, translating to highly regular bone formation with minimal fibrous tissue and increased bone density in rabbit radial defect models. Ionic colloidal molding is a simple yet effective approach of achieving materials homogeneity and modulating crystal nucleation, serving as an excellent biomimetic scaffolding strategy to rebuild natural bone integrity.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39016]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Zhongguancun North First St 2, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, 19 A Yuquan Rd, Beijing 100049, Peoples R China 3.Gen Hosp Chinese Peoples Liberat Army, Dept Orthopaed, 28 Fuxing Rd, Beijing 100853, Peoples R China 4.Penn State Univ, Huck Inst Life Sci, Mat Res Inst, Dept Biomed Engn, University Pk, PA 16802 USA
推荐引用方式 GB/T 7714	Zhang, Jian,Jia, Jinpeng,Kim, Jimin P.,et al. Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration[J]. ADVANCED MATERIALS,2017,29(17).
APA	Zhang, Jian.,Jia, Jinpeng.,Kim, Jimin P..,Shen, Hong.,Yang, Fei.,...&Wu, Decheng.(2017).Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration.ADVANCED MATERIALS,29(17).
MLA	Zhang, Jian,et al."Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration".ADVANCED MATERIALS 29.17(2017).