Construction of Injectable Double-Network Hydrogels for Cell Delivery

	Construction of Injectable Double-Network Hydrogels for Cell Delivery
	Yan, Yan 1; Li, Mengnan 2; Yang, Di 1; Wang, Qian 2; Liang, Fuxin 2; Qu, Xiaozhong 1; Qiu, Dong 2; Yang, Zhenzhong 2
刊名	BIOMACROMOLECULES
	2017-07-01
卷号	18 期号:7 页码:2128-2138
英文摘要	Herein we present a unique method of using dynamic cross-links, which are dynamic covalent bonding and ionic interaction, for the construction of injectable double-network (DN) hydrogels, with the objective of cell delivery for cartilage repair. Glycol chitosan and dibenzaldhyde capped poly(ethylene oxide) formed the first network, while calcium alginate formed the second one, and in the resultant DN hydrogel, either of the networks could be selectively removed. The moduli of the DN hydrogel were significantly improved compared to that of the parent single-network hydrogels and were tunable by changing the chemical components. In situ 3D cell encapsulation could be easily performed by mixing cell suspension to the polymer solutions and transferred through a syringe needle before sol gel transition. Cell proliferation and mediated differentiation of mouse chondrogenic cells were achieved in the DN hydrogel extracellular matrix.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38987]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yan,Li, Mengnan,Yang, Di,et al. Construction of Injectable Double-Network Hydrogels for Cell Delivery[J]. BIOMACROMOLECULES,2017,18(7):2128-2138.
APA	Yan, Yan.,Li, Mengnan.,Yang, Di.,Wang, Qian.,Liang, Fuxin.,...&Yang, Zhenzhong.(2017).Construction of Injectable Double-Network Hydrogels for Cell Delivery.BIOMACROMOLECULES,18(7),2128-2138.
MLA	Yan, Yan,et al."Construction of Injectable Double-Network Hydrogels for Cell Delivery".BIOMACROMOLECULES 18.7(2017):2128-2138.