Preparation of Polymer@AuNPs with Droplets Approach for Sensing Serum Copper Ions

	Preparation of Polymer@AuNPs with Droplets Approach for Sensing Serum Copper Ions
	Qiao, Juan 1,2,3; Ding, Hong 4; Liu, Qianrong 5; Zhang, Rongyue 4; Qi, Li 1,2,3,6
刊名	ANALYTICAL CHEMISTRY
	2017-02-07
卷号	89 期号:3 页码:2080-2085
英文摘要	A microfluidic droplet synthesis approach for the preparation of poly N-isopropylacrylamide protected gold nanoparticles (PNIPAm@AuNPs) was presented here. Well dispersed PNIPAm@AuNPs could be generated within 8 min. On the basis of the aggregation-induced UV vis adsorption intensity increasing mechanism, the PNIPAm@AuNPs-based colorimetric probe displayed high sensitivity and good selectivity for sensing copper ions. A linear calibration of relative UV vis adsorption intensity increasing versus copper ions concentration was obtained within 5.0-750.0 mu M, and the limit of detection was 2.5 mu M. Furthermore, after copper ions were injected in rat, a metabolic assay was developed with the proposed probe. The results indicated that the droplet microfluidic synthesis system could provide a new way for preparation of polymer@AuNPs with good polydispersity index and showed great potential of polymer@AuNPs-based sensing probe for application in biological and clinical analysis.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38133]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China 5.Xian Univ Sci & Technol, Xian 710054, Shaanxi, Peoples R China 6.2 Zhongguancun Beiyijie, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Juan,Ding, Hong,Liu, Qianrong,et al. Preparation of Polymer@AuNPs with Droplets Approach for Sensing Serum Copper Ions[J]. ANALYTICAL CHEMISTRY,2017,89(3):2080-2085.
APA	Qiao, Juan,Ding, Hong,Liu, Qianrong,Zhang, Rongyue,&Qi, Li.(2017).Preparation of Polymer@AuNPs with Droplets Approach for Sensing Serum Copper Ions.ANALYTICAL CHEMISTRY,89(3),2080-2085.
MLA	Qiao, Juan,et al."Preparation of Polymer@AuNPs with Droplets Approach for Sensing Serum Copper Ions".ANALYTICAL CHEMISTRY 89.3(2017):2080-2085.