Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes

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	Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes
	Qiao, Ruirui 1; Qiao, Hongyu 2,3; Zhang, Yan 2; Wang, Yabin 2; Chi, Chongwei 4; Tian, Jie 4; Zhang, Lifang 1; Cao, Feng 2; Gao, Mingyuan 1
刊名	ACS NANO
	2017-02-01
卷号	11 期号:2 页码:1816-1825
关键词	Vulnerable Plaques Macrophage Opn Molecular Imaging Upconversion Nanoparticle
英文摘要	Owing to the high mortality rate of cardiovascular diseases, developing novel noninvasive diagnostic methods becomes urgent and mandatory. It is well-known that the rupture of vulnerable plaques directly leads to deadly consequences. However, differentiating vulnerable plaques from stable plaques remains challenging in the clinic. In the current study, osteopontin (OPN), a secreted biomarker associated with macrophages and foamy macrophages, was selected as a target for identifying the vulnerable plaques. A dual modality imaging probe was constructed by covalently attaching an OPN antibody to NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles. Upon intravenous injection resulting probes, upconversion optical imaging was performed to visualize the plaques induced by altering the shear stress in carotid arteries of a mouse model. The imaging studies revealed that the signals of vulnerable and stable plagues induced by lowered shear stress and oscillatory shear stress, respectively, presented significantly different signal intensities, implying that the current probe and imaging strategy are potentially useful for a precise diagnosis of atherosclerosis plaques.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38131]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, 28 Fuxing Rd, Beijing 100853, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China 4.Chinese Acad Sci, Key Lab Mol Imaging, 95 Zhong Guan Cun East Rd, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Ruirui,Qiao, Hongyu,Zhang, Yan,et al. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes[J]. ACS NANO,2017,11(2):1816-1825.
APA	Qiao, Ruirui.,Qiao, Hongyu.,Zhang, Yan.,Wang, Yabin.,Chi, Chongwei.,...&Gao, Mingyuan.(2017).Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes.ACS NANO,11(2),1816-1825.
MLA	Qiao, Ruirui,et al."Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes".ACS NANO 11.2(2017):1816-1825.