Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity

	Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity
	Bai, Haotian 1; Zhang, Hongyi 2; Hu, Rong 1; Chen, Hui 1; Lv, Fengting 1; Liu, Libing 1; Wang, Shu 1
刊名	LANGMUIR
	2017-01-31
卷号	33 期号:4 页码:1116-1120
英文摘要	Infections of antibiotic-resistant pathogens have caused a series of public health crises across the world. According to the latest published reports, an antibiotic switch has been recognized as a potential strategy to control antibacterial activity for combating this serious drug resistance. Thus, it is anticipated that more effective antibiotic switches should be obtained by further exploring the developed strategies. Here, we report an improved pretreatment strategy using a surfactant (Triton X-100) for constructing an effective supramolecular antibiotic switch based on a poly(fluorene-cophenylene) derivative (PFP) and cucurbit[7]uril (CB[7]), which can regulate the aggregation state of polymers before the supramolecular self-assembly process occurs. Triton X-100 can regulate the aggregation states of conjugated polymers, which is used to successfully realize the reversible control of bactericidal activity of PFP in the dark and under white light irradiation by supramolecular assembly/disassembly between PFP and CB[7]. Specialized antibiotic switches are significantly important to fight pathogenic infections and solve the drug resistance crisis in the future.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38060]
专题	化学研究所_有机固体实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China 2.Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
推荐引用方式 GB/T 7714	Bai, Haotian,Zhang, Hongyi,Hu, Rong,et al. Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity[J]. LANGMUIR,2017,33(4):1116-1120.
APA	Bai, Haotian.,Zhang, Hongyi.,Hu, Rong.,Chen, Hui.,Lv, Fengting.,...&Wang, Shu.(2017).Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity.LANGMUIR,33(4),1116-1120.
MLA	Bai, Haotian,et al."Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity".LANGMUIR 33.4(2017):1116-1120.