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	Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
	Zhao, Yan-Li1,2; He, Qiu-Xia3; Li, Yang1; Wang, Si-Feng3; Liu, Ke-Chun3; Yang, Yong-Ping1,4; Li, Xiao-Li1,4
刊名	MOLECULES
	2010-04-01
卷号	15期号:4页码:2178-2186
关键词	Kaurane Diterpenoid Excoecaria Acerifolia Nmr Antiangiogenic Antiproliferative
ISSN号	1420-3049
DOI	10.3390/molecules15042178
文献子类	Article
英文摘要	A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.; A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
学科主题	Chemistry, Organic
WOS关键词	DITERPENOIDS ; GLYCOSIDES ; AGALLOCHA
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000277147400012
资助机构	West Light Foundation of the Chinese Academy of Sciences ; MOST [2008BAD98B06]; MAPPA/ICIMOD ; Ford Foundation [1075-0729, 1090-0448]
公开日期	2011-12-06
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/2617]
专题	昆明植物研究所_中国科学院青藏高原研究所昆明部
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China 4.Chinese Acad Sci, Inst Tibetan Plateau Res Kunming, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yan-Li,He, Qiu-Xia,Li, Yang,et al. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities[J]. MOLECULES,2010,15(4):2178-2186.
APA	Zhao, Yan-Li.,He, Qiu-Xia.,Li, Yang.,Wang, Si-Feng.,Liu, Ke-Chun.,...&Li, Xiao-Li.(2010).Chemical Constituents of Excoecaria acerifolia and Their Bioactivities.MOLECULES,15(4),2178-2186.
MLA	Zhao, Yan-Li,et al."Chemical Constituents of Excoecaria acerifolia and Their Bioactivities".MOLECULES 15.4(2010):2178-2186.

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