Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis

doi:10.1016/j.antiviral.2009.08.004

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	Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis
	Ya-Feng, Wang 1,2; Xiao-Yan, Wang 1,2; Zhe, Ren 1,2; Chui-Wen, Qian 1,2; Yi-Cheng, Li 1,2; Kitazato, Kaio 1,3; Qing-Duan, Wang 4; Yan, Zhang 4; Li-Yun, Zheng 4; Jin-Hua, Jiang 4
刊名	ANTIVIRAL RESEARCH
	2009-11-01
卷号	84 期号:2 页码:150-158
关键词	Coxsackie Virus B3 Viral Myocarditis Phyllaemblicin b Antiviral Effect Apoptosis
ISSN号	0166-3542
DOI	10.1016/j.antiviral.2009.08.004
通讯作者	twang-yf@163.com
文献子类	Article
英文摘要	Coxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. in this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells with an IC50 value of 7.75 +/- 0.15 mu g/mL In an in vivo assay, treatment with 12 mg kg(-1) d(-1) Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis. Therefore CVB3. (C) 2009 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Virology
WOS关键词	DILATED CARDIOMYOPATHY ; B3-INDUCED MYOCARDITIS ; VIRAL MYOCARDITIS ; GLUTATHIONE-PEROXIDASE ; CYTOCHROME-C ; IN-VITRO ; INFECTION ; ACTIVATION ; RELEASE ; CELLS
WOS研究方向	Pharmacology & Pharmacy ; Virology
语种	英语
WOS记录号	WOS:000271171800005
资助机构	This study was supported by the joint Funds of National Science Foundation of China (U0632010), the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (P2008-KF07, P2008-ZZ08) and "211 grant of the Ministry of Education (MOE)".
公开日期	2011-12-06
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/2399]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位	1.Jinan Univ, Inst Pharmacol Sci, Guangzhou 510630, Guangdong, Peoples R China 2.Natl Engn Res Ctr Genet Med, Guangzhou 510630, Guangdong, Peoples R China 3.Nagasaki Univ, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Lab Mol Biol Infect Agents, Nagasaki 852, Japan 4.Zhengzhou Univ, Henan Acad Med & Pharmaceut Sci, Zhengzhou 450000, Henan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Ya-Feng, Wang,Xiao-Yan, Wang,Zhe, Ren,et al. Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis[J]. ANTIVIRAL RESEARCH,2009,84(2):150-158.
APA	Ya-Feng, Wang.,Xiao-Yan, Wang.,Zhe, Ren.,Chui-Wen, Qian.,Yi-Cheng, Li.,...&Yi-Fei, Wang.(2009).Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis.ANTIVIRAL RESEARCH,84(2),150-158.
MLA	Ya-Feng, Wang,et al."Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis".ANTIVIRAL RESEARCH 84.2(2009):150-158.