Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora | |
Ding, Lin-Fen1,2,3; Su, Jia1; Pan, Zheng-Hong4; Zhang, Zhi-Jun1; Li, Xiao-Nian1; Song, Liu-Dong2,3; Wu, Xing-De1; Zhao, Qin-Shi1 | |
刊名 | PHYTOCHEMISTRY |
2018-11-01 | |
卷号 | 155页码:182-190 |
关键词 | Magnolia Grandiflora (Magnoliaceae) Sesquiterpenoids Cytotoxic Activity Nf-kappa b Transcriptional Activity |
ISSN号 | 0031-9422 |
DOI | 10.1016/j.phytochem.2018.08.006 |
英文摘要 | Nine previously undescribed sesquiterpenoids, named magnograndins A-I, as well as fourteen known ones, were obtained from the 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were ascertained based on the spectroscopic evidences. The assignment of the relative configuration of magnograndin A was further confirmed by single-crystal X-ray diffraction analysis. 113,10a-Epoxyparthenolide, parthenolide, and micheliolide exhibited potent cytotoxic activity against MDA-MB-468, AGS, HCT116, Hela, and MDA-MB-231 human cancer cell lines with IC50 values ranging from 1.76 to 16.11 mu M. 1 beta,10 alpha-Epoxyparthenolide and micheliolide potently inhibited NF-kappa B transcriptional activity with IC50 of 13.92 and 8.95 mu M, respectively. The expression levels of NF-kappa B downstream protein p65 and XIAP were clearly down-regulated in 1 beta,10 alpha-epoxyparthenolide and micheliolide treated cells, which demonstrated the inhibition of NF-kappa B signaling pathway. |
资助项目 | Natural Science Foundation of China[21662023] ; Natural Science Foundation of China[81773611] ; Natural Science Foundation of China[21602227] ; Yunnan Applied Basic Research-Joint Special Project of Kunming Medical University[2017FE467-016] ; Science Research Foundation of Yunnan Provincial Education Department[2017zDX156] ; Guangxi Key Laboraratory of Functional Phytochemical Research and Utilization[FPRU2016-3] ; NSFC-Joint Foundation of Yunnan Province[U1502223] ; Science and Technology Program of Yunnan province[2015FB173] ; Science and Technology Program of Yunnan province[2016FB140] ; CAS "Light of West China" Program ; Youth Innovation Promotion Association CAS |
WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000447483900021 |
资助机构 | Natural Science Foundation of China ; Yunnan Applied Basic Research-Joint Special Project of Kunming Medical University ; Science Research Foundation of Yunnan Provincial Education Department ; Guangxi Key Laboraratory of Functional Phytochemical Research and Utilization ; NSFC-Joint Foundation of Yunnan Province ; Science and Technology Program of Yunnan province ; CAS "Light of West China" Program ; Youth Innovation Promotion Association CAS |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/62788] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
通讯作者 | Wu, Xing-De; Zhao, Qin-Shi |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 4.Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China |
推荐引用方式 GB/T 7714 | Ding, Lin-Fen,Su, Jia,Pan, Zheng-Hong,et al. Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora[J]. PHYTOCHEMISTRY,2018,155:182-190. |
APA | Ding, Lin-Fen.,Su, Jia.,Pan, Zheng-Hong.,Zhang, Zhi-Jun.,Li, Xiao-Nian.,...&Zhao, Qin-Shi.(2018).Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora.PHYTOCHEMISTRY,155,182-190. |
MLA | Ding, Lin-Fen,et al."Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora".PHYTOCHEMISTRY 155(2018):182-190. |
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