A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336

doi:10.1080/14786419.2017.1338285

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336
	Yu, Fei-Xue 1,2,3; Chen, Yao 3; Yang, Yin-He 4; Li, Guo-Hong 1,2; Zhao, Pei-Ji 1,2,4
刊名	NATURAL PRODUCT RESEARCH
	2018
卷号	32 期号:6 页码:689-694
关键词	Chaetomium Sp M336 Chemical Constituents Structure Identification 6-formamide-chetomin Cytotoxicity Antibacterial Activities
ISSN号	1478-6419
DOI	10.1080/14786419.2017.1338285
英文摘要	A new compound 6-formamide-chetomin (1) together with chetomin (2) was isolated from solid fermentation products of the endophytic fungus Chaetomium sp. M336, which were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HR-ESI-MS experiments. The bioassay result showed that compound 1 had strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) value of 0.78 mu g/mL; meanwhile it exhibited strong cytotoxicity with IC50 values of 21.627.1 nM against cell lines HeLa, SGC-7901 and A549.
语种	英语
WOS记录号	WOS:000426942800010
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60529]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Minist Educ, State Key Lab Conservat & Utilizat Bioresources Y, Kunming, Yunnan, Peoples R China 2.Yunnan Univ, Minist Educ, Key Lab Microbial Resources, Kunming, Yunnan, Peoples R China 3.Kunming Univ Sci & Technol, Fac Med, Kunming, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yu, Fei-Xue,Chen, Yao,Yang, Yin-He,et al. A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336[J]. NATURAL PRODUCT RESEARCH,2018,32(6):689-694.
APA	Yu, Fei-Xue,Chen, Yao,Yang, Yin-He,Li, Guo-Hong,&Zhao, Pei-Ji.(2018).A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336.NATURAL PRODUCT RESEARCH,32(6),689-694.
MLA	Yu, Fei-Xue,et al."A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336".NATURAL PRODUCT RESEARCH 32.6(2018):689-694.