Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera

doi:10.1021/acs.jafc.8b00287

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera
	Chen, He-Ping 1; Zhao, Zhen-Zhu 1,2; Li, Zheng-Hui 1; Huang, Ying 1; Zhang, Shuai-Bing 1; Tang, Yang 1,2; Yao, Jian-Neng 1,2; Chen, Lin 1; Isaka, Masahiko 3; Feng, Tao 1
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2018-03-28
卷号	66 期号:12 页码:3146-3154
关键词	Mushroom Macrolepiota Procera Lanostane Triterpenoid Anti-inflammatory Activity Cytotoxicity
ISSN号	0021-8561
DOI	10.1021/acs.jafc.8b00287
英文摘要	This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A-L, 1-12, from the fruiting bodies of the Poland-collected edible mushroom Macrolepiota procera. The structures and the absolute configurations of the new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analyses. Structurally, lepiotaprocerins A-F, 1-6, are distinguished by the presence of a rare "1-en-1,11-epoxy" moiety which has not been previously described in the lanostane class. Biologically, lepiotaprocerins A-F, 1-6, displayed more significant inhibitions of nitric oxide (NO) production than the positive control L-N-G-monomethyl arginine (L-NMMA) (IC50 47.1 mu M), and lepiotaprocerins G-L, 7-12, showed various cytotoxicity potencies against a panel of human cancer cell lines. Compound 9 also displayed antitubercular activity against Mycobacterium tuberculosis H37Ra with a minimal inhibitory concentration (MIC) 50 mu g/mL.
语种	英语
WOS记录号	WOS:000428972400013
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60503]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.South Cent Univ Nationalities, Coll Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Natl Ctr Genet Engn & Biotechnol BIOTEC, 113 Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathumthani, Thailand
推荐引用方式 GB/T 7714	Chen, He-Ping,Zhao, Zhen-Zhu,Li, Zheng-Hui,et al. Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(12):3146-3154.
APA	Chen, He-Ping.,Zhao, Zhen-Zhu.,Li, Zheng-Hui.,Huang, Ying.,Zhang, Shuai-Bing.,...&Liu, Ji-Kai.(2018).Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(12),3146-3154.
MLA	Chen, He-Ping,et al."Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.12(2018):3146-3154.