Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity

doi:10.1021/acs.jnatprod.7b00163

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity
	Jiang, Hua-Yi 1,2,3,4; Wang, Wei-Guang 1,2; Tang, Jian-Wei 1,2; Liu, Miao 1,2; Li, Xing-Ren 1,2; Hu, Kun1,2 ; Du, Xue 1,2; Li, Xiao-Nian 1,2; Zhang, Hong-Bin 4; Pu, Jian-Xin1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2017-07-01
卷号	80 期号:7 页码:2026-2036
关键词	Ent-kaurane Diterpenoids Isodon-scoparius Cytotoxic Diterpenoids Abietane Diterpenoids Eriocalyxin-b Derivatives Laxiflora Growth
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.7b00163
英文摘要	Fourteen new diterpenoids (1-14) based on four skeletal types and two known analogues (15 and 16) were isolated from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring a 1,11-ether bridge, and the structures of these new compounds were established mainly by NMR and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined using single-crystal X-ray diffraction. The absolute configuration of 14 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and they also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values of 1.0, 3.1, and 1.8 mu M, respectively.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000406818300009
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/54947]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Hua-Yi,Wang, Wei-Guang,Tang, Jian-Wei,et al. Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(7):2026-2036.
APA	Jiang, Hua-Yi.,Wang, Wei-Guang.,Tang, Jian-Wei.,Liu, Miao.,Li, Xing-Ren.,...&Sun, Han-Dong.(2017).Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity.JOURNAL OF NATURAL PRODUCTS,80(7),2026-2036.
MLA	Jiang, Hua-Yi,et al."Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity".JOURNAL OF NATURAL PRODUCTS 80.7(2017):2026-2036.