Diterpenoid Constituents of the Roots of Salvia digitaloides

doi:10.1021/jf103366g

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Diterpenoid Constituents of the Roots of Salvia digitaloides
	Xu, Gang1 ; Yang, Jing2 ; Wang, Yuan-Yuan 1; Peng, Li-Yan 1; Yang, Xian-Wen 3; Pan, Zheng-Hong 1; Liu, En-De1 ; Li, Yan1 ; Zhao, Qin-Shi1
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2010-12-08
卷号	58 期号:23 页码:12157-12161
关键词	Salvia Digitaloides Cytotoxic Activity Diterpenoids Stereochemistry
ISSN号	0021-8561
DOI	10.1021/jf103366g
文献子类	Article
英文摘要	Salvia digitaloides, belonging to the economically and medicinally important genus Salvia, is distributed in the northwest of Yunnan Province, People's Republic of China. The roots of this plant were soaked in alcohol by local Tibetans to make a special traditional "red wine", and many local people like to drink this traditional "red wine" to strengthen physical health. To investigate the bioactive diterpenoid constituents of the roots, a detailed phytochemical study was carried out, and 13 diterpenoids including two new norditerpenoids, dihydroneotanshinlactone (1) and 16,17-dinorpisferal A (2), were isolated. Their structures were established on the basis of detailed spectroscopic analysis. In addition, computational methods were applied to validate the stereochemistry of compound 1. For the bioassay to inhibit the growth of five tumor cell lines, neotanshinlactone (3) exhibited selective cytotoxic activity toward the human breast cancer cell line SK-BR-3, while the other four tanshinones (4-7) showed significant toxicity effects against all of the tested five cell lines.
学科主题	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS关键词	BIOLOGICAL EVALUATION ; NEO-TANSHINLACTONE ; ANTITUMOR AGENTS ; CANCER AGENTS ; MILTIORRHIZA ; POTENT ; CONTINUUM ; MODEL ; DNA
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
WOS记录号	WOS:000284672800015
资助机构	National Basic Research Program of China (973 Program) [2009CB522300]; National Natural Science Foundation of China [20702054]; Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2008-ZZ27]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2009CI073]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4948]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Xu, Gang,Yang, Jing,Wang, Yuan-Yuan,et al. Diterpenoid Constituents of the Roots of Salvia digitaloides[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(23):12157-12161.
APA	Xu, Gang.,Yang, Jing.,Wang, Yuan-Yuan.,Peng, Li-Yan.,Yang, Xian-Wen.,...&Zhao, Qin-Shi.(2010).Diterpenoid Constituents of the Roots of Salvia digitaloides.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,58(23),12157-12161.
MLA	Xu, Gang,et al."Diterpenoid Constituents of the Roots of Salvia digitaloides".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58.23(2010):12157-12161.