Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats

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	Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats
	Adebayo, Abiodun Humphrey 1,2; Zeng, Guang-Zhi 1; Fan, Jun-Ting 1; Ji, Chang-Jiu 1; He, Wen-Jun 1; Xu, Jun-Ju 1; Zhang, Yu-Mei 1; Akindahunsi, Afolabi Akintunde 3; Kela, Roseline 4; Tan, Ning-Hua 1
刊名	JOURNAL OF MEDICINAL PLANTS RESEARCH
	2010-11-04
卷号	4 期号:21 页码:2264-2272
关键词	Ageratum Conyzoides Asteraceae Liver Markers Histopathological Study Toxicological Study
ISSN号	1996-0875
文献子类	Article
英文摘要	This study was conducted to evaluate the safety potential of the leaf extract of Ageratum conyzoides Linnaeus in Sprague Dawley (SD) rats using biochemical, haematological and histological indices of toxicity. Four groups of seven male SD rats per group were used for the study. To group A was administered 0.25% CMC-Na/kg body weight and was used as the control group, while groups B, C and D were respectively administered with 500, 1000 and 1500 mg/kg body weight of the ethanolic leaf extract of A. conyzoides by gastric intubation for 14 days. Animals were subsequently anaesthetized, blood samples were collected for biochemical and haematological assays; organs were isolated and weighed, while the liver, kidney and spleen were processed for histopathological studies. Aspartate amino transferase, lactate dehydrogenase, creatine kinase and alkaline phosphatase were significantly (p < 0.05) reduced in the groups treated with 1000 and 1500 mg/kg body weight of the extract. Furthermore, there was a significant (p < 0.05) elevation in white blood cell count, mean platelet volume and % platelet distribution width. Histopathological studies indicated various degrees of hepatocellular necrosis in all the treated groups accompanied by significant increases in the weight of liver and spleen. The results showed that the ethanolic leaf extract of A. conyzoides significantly alters the biomarkers of cardiac and skeletal muscle disorders, and higher doses could induce liver cell injury.
学科主题	Chemistry, Medicinal
WOS关键词	CATALYTIC CONCENTRATION ; MYOCARDIAL-INFARCTION ; IFCC METHODS ; TOXICITY ; BIOMARKERS ; PARAMETERS ; ASTERACEAE ; ENZYMES ; LEAVES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000285689600015
资助机构	Chinese Academy of Sciences (CAS) ; Academy of Sciences for the Developing World (TWAS) ; National Natural Science Foundation of China [30725048]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4912]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria 3.Fed Univ Technol Akure, Dept Biochem, Akure, Ondo State, Nigeria 4.Energy Commiss Nigeria, Garki Cenral Area, Abuja, FCT, Nigeria
推荐引用方式 GB/T 7714	Adebayo, Abiodun Humphrey,Zeng, Guang-Zhi,Fan, Jun-Ting,et al. Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH,2010,4(21):2264-2272.
APA	Adebayo, Abiodun Humphrey.,Zeng, Guang-Zhi.,Fan, Jun-Ting.,Ji, Chang-Jiu.,He, Wen-Jun.,...&Tan, Ning-Hua.(2010).Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats.JOURNAL OF MEDICINAL PLANTS RESEARCH,4(21),2264-2272.
MLA	Adebayo, Abiodun Humphrey,et al."Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats".JOURNAL OF MEDICINAL PLANTS RESEARCH 4.21(2010):2264-2272.